公开(公告)号：WO2021011466A1

公开(公告)日：2021-01-21

申请号：PCT/US2020/041796

申请日：2020-07-13

Applicant: ATTOSTAT, INC.

Inventor： NIEDERMEYER, William

IPC: A61K31/712 ,  A61K45/06 ,  A61K9/08

Abstract: This disclosure relates to metal nanoparticle compositions and methods for treating respiratory infections associated with cystic fibrosis. An amount of nonionic, ground state metal nanoparticles are administered to a patient via inhalation. The metal nanoparticles have properties that enable effective transport through the viscous mucus layer to the epithelia and surrounding tissues, killing or deactivating infecting microbes at the targeted respiratory tissue and throughout the overlying mucus layer.

公开(公告)号：WO2013006430A2

公开(公告)日：2013-01-10

申请号：PCT/US2012/044907

申请日：2012-06-29

Applicant: ATTOSTAT, INC. ,  NIEDERMEYER, William

Inventor： NIEDERMEYER, William

CPC classification number: B22F9/04 ,  B01J13/0043 ,  B22F1/0018 ,  B22F3/003 ,  B22F2009/045 ,  B22F2999/00 ,  B82Y40/00 ,  Y10T428/2982 ,  B22F2202/11 ,  B22F2202/06 ,  B22F2202/05

Abstract: An apparatus and process for creating uniformly sized, spherical nanoparticles from a solid target. The solid target surface is ablated to create an ejecta event containing nanoparticles moving away from the surface. Ablation may be caused by laser or electrostatic discharge. At least one electromagnetic field is placed in front of the solid target surface being ablated. The electromagnetic field manipulates at least a portion of the nanoparticles as they move away from the target surface through the electromagnetic field to increase size and spherical shape uniformity of the nanoparticles. The manipulated nanoparticles are collected.

Abstract translation: 用于从固体靶产生均匀尺寸的球形纳米粒子的装置和方法。 固体靶表面被烧蚀以产生包含从表面移开的纳米颗粒的喷射事件。 可能由激光或静电放电引起消融。 至少一个电磁场被放置在被烧蚀的固体靶表面的前面。 当电磁场通过电磁场离开目标表面时，电磁场操纵至少一部分纳米颗粒，以增加纳米颗粒的尺寸和球形均匀性。 收集操纵的纳米粒子。

公开(公告)号：WO2022046977A1

公开(公告)日：2022-03-03

申请号：PCT/US2021/047674

申请日：2021-08-26

Applicant: ATTOSTAT, INC.

Inventor： NIEDERMEYER, William

IPC: A61Q11/00 ,  A61K6/17 ,  A61K33/24 ,  B82Y5/00

Abstract: A nanoparticle composition for oral care includes at least one of a first set of spherical nanoparticles or a second set of coral shaped nanoparticles, and a stabilizing agent. The nanoparticle composition is added to a carrier suitable for application to an oral cavity, including to teeth and surrounding oral tissues. The nanoparticle composition is configured to control the pH of the microenvironment to which it is applied, thereby preventing and/or treating a variety of oral conditions. The nanoparticle composition can be provided as a concentrated nanoparticle additive addable to a mouthwash, mouth rinse, dentifrice, mouth spray, oral gel, denture cleaning solution, or other carrier suitable for oral application.