公开(公告)号：WO2022035692A1

公开(公告)日：2022-02-17

申请号：PCT/US2021/044909

申请日：2021-08-06

Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.

Inventor： KHLEIF, Samir N. ,  MKRTICHYAN, Mikayel ,  LEBEDYEVA, Iryna ,  ALBERS, Thomas

IPC: A61K31/4709 ,  C07D401/14 ,  A61K31/4985

Abstract: Compounds and compositions for selectively modulating Akt3 are provided. Methods of using the compounds are also provided. Because Akt3 modulates the suppressive function of natural Tregs and the polarization of induced Tregs, the disclosed compounds are useful for modulating immune responses.

公开(公告)号：WO2021212111A1

公开(公告)日：2021-10-21

申请号：PCT/US2021/027987

申请日：2021-04-19

Applicant: AUGUSTA UNIVERSITY RESEARCH INSTITUTE, INC.

Inventor： KHLEIF, Samir N.

IPC: A61K39/00 ,  A61K39/39 ,  A61P35/00

Abstract: Compositions and methods for treating leukemia are provided herein. One embodiment provides a method of treating leukemia in a subject in need thereof by administering to a subject in need thereof a composition that selectively inhibits Akt3 by an amount effective to reduce the immune suppressive response in the subject. In one embodiment, the Akt3 inhibitors include, but are not limited to, compounds 1-31 and Formulas I-III.