公开(公告)号：WO2020123861A1

公开(公告)日：2020-06-18

申请号：PCT/US2019/066066

申请日：2019-12-12

申请人： AUTOBAHN THERAPEUTICS, INC. ,  BACKES, Bradley

发明人： BACKES, Bradley ,  VON GELDERN, Thomas ,  POUPON, Jean-Christophe

IPC分类号： C07C59/70 ,  C07C69/736 ,  C07C235/20 ,  A61P25/00

摘要： Compounds are provided having the following structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X1, X2, and R1 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.

公开(公告)号：WO2020118564A1

公开(公告)日：2020-06-18

申请号：PCT/CN2018/120634

申请日：2018-12-12

申请人： AUTOBAHN THERAPEUTICS, INC.

发明人： VON GELDERN, Thomas ,  POUPON, Jean-Christophe

IPC分类号： C07C15/16 ,  C07C25/06 ,  A61P5/14

摘要： Compounds are provided having the structure of Formula (I) : (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X 1 , X 2 , and R 1 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.