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公开(公告)号：WO2020118564A1
公开(公告)日：2020-06-18
申请号：PCT/CN2018/120634
申请日：2018-12-12
摘要： Compounds are provided having the structure of Formula (I) : (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X 1 , X 2 , and R 1 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
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公开(公告)号：WO2021257834A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037833
申请日：2021-06-17
IPC分类号： C07C233/22
摘要： Compounds are provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.
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公开(公告)号：WO2020123861A1
公开(公告)日：2020-06-18
申请号：PCT/US2019/066066
申请日：2019-12-12
IPC分类号： C07C59/70 , C07C69/736 , C07C235/20 , A61P25/00
摘要： Compounds are provided having the following structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein X1, X2, and R1 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
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公开(公告)号：WO2021257851A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037862
申请日：2021-06-17
发明人： VON GELDERN, Thomas , BACKES, Bradley , STEARNS, Brian Andrew , BACCEI, Jill Melissa , HARRIS, Jason Randall
IPC分类号： C07C69/732
摘要： Compounds provided herein function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.
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公开(公告)号：WO2021247847A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035679
申请日：2021-06-03
IPC分类号： C07C237/12 , C07C69/708 , A61P1/00 , C07B2200/05 , C07C235/20
摘要： Isotopic compounds are provided that function as thyromimetics, which compounds have utility for treating diseases such as neurodegenerative disorders. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
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公开(公告)号：WO2020180624A1
公开(公告)日：2020-09-10
申请号：PCT/US2020/020199
申请日：2020-02-27
IPC分类号： C07D203/18 , C07D205/04 , C07D207/08 , C07D211/06 , C07D213/55 , C07D239/26 , C07D307/54 , C07D333/24 , A61K31/341 , A61K31/381 , A61K31/4409 , A61K31/505 , A61P5/14 , A61P25/28
摘要： Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, X 1 , X 2 , Q, R 1 , R 2 and n are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
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公开(公告)号：WO2022236133A1
公开(公告)日：2022-11-10
申请号：PCT/US2022/028187
申请日：2022-05-06
IPC分类号： A61K31/44 , A61K31/165 , A61K31/4965 , A61K31/505 , A61K31/50 , A61K31/42 , A61K31/397 , A61K31/40 , A61K31/5375 , C07D213/75 , C07D241/20 , C07D261/14 , C07D237/20 , C07D239/42 , C07D205/04 , C07D295/185 , C07C235/22 , C07C235/06 , C07C243/28 , C07C235/08 , A61P25/28
摘要： Provided herein are fatty acid amide (FAAH) cleavable prodrugs of thyromimetics and pharmaceutical compositions comprising these compounds with at least one pharmaceutically acceptable excipient further comprising a peripherally restricted FAAH inhibitor.
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公开(公告)号：WO2022236118A1
公开(公告)日：2022-11-10
申请号：PCT/US2022/028164
申请日：2022-05-06
IPC分类号： C07C235/20 , C07C235/22 , C07D205/04 , C07D209/94 , A61K31/16 , A61K31/397 , A61K31/403 , A61K31/415 , A61K31/42 , A61K31/421 , A61K31/423 , A61K31/44 , A61K31/443 , A61K31/501 , A61K31/549 , A61P25/00 , A61P25/14 , A61P25/16 , A61P25/18 , A61P25/24 , A61P25/28 , C07D213/75 , C07D231/12 , C07D237/20 , C07D261/14 , C07D263/58 , C07D307/78 , C07D401/12 , C07D403/12 , C07D405/12 , C07D413/12
摘要： Provided herein are fatty acid amide (FAAH) cleavable prodrugs of compounds that modulate a target in the brain including sphingosine- 1 -phosphate receptor (S1P1), lysophosphatidic acid receptor 1 (LPA1), G-protein coupled receptor 120 (GPR120), prostacyclin (PGI2), and transthyretin (TTR). Pharmaceutical compositions comprising these prodrugs, including in combination with a peripherally restricted FAAH inhibitor, and at least one pharmaceutically acceptable excipient, are also provided, and the use of these compounds and compositions in the treatment of CNS diseases or disorders.
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公开(公告)号：WO2021257804A1
公开(公告)日：2021-12-23
申请号：PCT/US2021/037788
申请日：2021-06-17
IPC分类号： A61K31/192 , A61K31/661 , A61K31/662
摘要： Disclosed herein are thyromimetic compounds having utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their preparation.
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公开(公告)号：WO2021108549A1
公开(公告)日：2021-06-03
申请号：PCT/US2020/062229
申请日：2020-11-25
发明人： GELDERN, Thomas von , BACKES, Bradley , HE, Baoku , HARRIS, Jason
IPC分类号： A61K31/192 , A61K31/661 , A61K31/662
摘要： Compounds are provided having the structure of Formula (I) or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein R1, R2, X1, X2, Y1, and Y2 are as defined herein. Such compounds function as thyromimetics and have utility for treating diseases such as neurodegenerative disorders and fibrotic diseases. Pharmaceutical compositions containing such compounds are also provided, as are methods of their use and preparation.
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