公开(公告)号：WO2004037172A2

公开(公告)日：2004-05-06

申请号：PCT/US0332408

申请日：2003-10-10

Applicant: AVRAM ELENA

Inventor： AVRAM ELENA

IPC: A61K31/20 ,  C07C391/00 ,  A61K

CPC classification number: A61K31/20 ,  C07C391/00

Abstract: A composition of selenium monobromide-oil reaction product including a reaction product of selenium momobromide-in-oil prepared from eleostearic acid and selenium monobromide, which contains at least about 0.1 percent of selenium monobromide and exhibits ultraviolet absorption maxima typical of conjugated trienes and conjugated dienes and pharmaceutical composition thereof for administration to a subject in a therapeutically effective amount to treat neoplastic conditions such as cancer. Methods of making such compositions are also encompassed, as are methods for treating neoplastic conditions by administering to a subject an effective amount of a selenium monobromide-oil reaction product with epichlorohydrin.

Abstract translation: 一溴代硒油反应产物的组合物，其包含由单硬脂酸和一溴化硒制备的硒一溴溴化物的反应产物，其含有至少约0.1％的一溴化硒并且表现出典型的共轭三烯和共轭二烯的紫外吸收最大值 及其药物组合物，其用于以治疗有效量施用于受试者以治疗肿瘤性疾病如癌症。 还包括制备这种组合物的方法，以及通过向受试者施用有效量的一氧化碳 - 油反应产物与表氯醇来治疗肿瘤病症的方法。