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公开(公告)号：WO2020157194A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052287
申请日：2020-01-30
发明人： GRADL, Stefan, Nikolaus , ELLERMANN, Manuel , LIENAU, Philip , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , SÜLZLE, Detlev , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D253/06 , C07D403/10 , C07D403/12 , C07C229/08 , A61P35/00 , A61K31/53
摘要： The present invention includes name compounds of general formula (I) : (I) in which R 1 , R 2 , R 3 and R 4 are as defined herein, methods for their preparation, pharmaceutical compositions and combinations comprising said compounds, and their use for the treatment of hyperproliferative diseases.
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2.发明申请
公开(公告)号：WO2019025554A1
公开(公告)日：2019-02-07
申请号：PCT/EP2018/071016
申请日：2018-08-02
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , DANA-FARBER CANCER INSTITUTE, INC.
发明人： ELLERMANN, Manuel , GRADL, Stefan, Nikolaus , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , SÜLZLE, Detlev , LEWIS, Timothy , GREULICH, Heidi , WU, Xiaoyun , MEYERSON, Matthew
IPC分类号： C07D237/04 , C07D401/10 , C07D403/10 , C07D405/10 , C07D413/10 , A61K31/50 , A61K31/501 , A61P35/00
摘要： The present invention provides 6-phenyl-4,5-dihydropyridazin-3(2H)- one derivatives of formula (I) : The present invention provides 6-phenyl-4,5-dihydropyridazin-3(2H)- one derivatives of formula (I) :
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公开(公告)号：WO2020157199A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052293
申请日：2020-01-30
发明人： ELLERMANN, Manuel , GRADL, Stefan, Nikolaus , SÜLZLE, Detlev , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D403/10 , C07D237/26 , C07D403/12 , A61P35/00 , A61P37/00 , A61K31/504
摘要： The present invention includes name compounds of general formula (I) : (I), in which R 1 , R 2 , R 3 and A are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：WO2020157188A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052276
申请日：2020-01-30
发明人： ELLERMANN, Manuel , GRADL, Stefan, Nikolaus , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , HERBERT, Simon, Anthony , SÜLZLE, Detlev , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D273/04 , A61K31/5395 , A61P35/00
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I) : (I), in which R 1 , R 2 , R 3 , and R 4 , are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：WO2020157236A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052355
申请日：2020-01-30
发明人： ELLERMANN, Manuel , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun
IPC分类号： C07D413/04 , C07D413/14 , A61P35/00 , A61K31/5395
摘要： The present invention includes name compounds of general formula (I) : in which R 1 , R 3 and R 4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：WO2020157189A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052279
申请日：2020-01-30
发明人： ELLERMANN, Manuel , GRADL, Stefan, Nikolaus , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , SÜLZLE, Detlev , HERBERT, Simon, Anthony , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun , CARR, James, Lindsay , INGRAM, Peter, Neville , SHEPHERD, Jon , STIMSON, Christopher , BROOKFILED, Frederick
IPC分类号： C07D253/06 , C07C233/00 , C07D401/12 , C07D403/12 , C07D405/12 , A61P35/00 , A61K31/53
摘要： The present invention includes name compounds of general formula (I) in which R 1 , Y, R 3 and R 4 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：WO2020157201A1
公开(公告)日：2020-08-06
申请号：PCT/EP2020/052295
申请日：2020-01-30
发明人： ELLERMANN, Manuel , GRADL, Stefan, Nikolaus , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , SÜLZLE, Detlev , HERBERT, Simon, Anthony , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun , CARR, James, Lindsay , INGRAM, Peter, Neville , SHEPHERD, Jon , STIMSON, Christopher , BROOKFILED, Frederick
IPC分类号： C07D211/36 , A61K31/5395 , C07D273/04 , C07D295/14 , C07D413/10 , C07D413/12 , A61P35/00
摘要： The present invention includes name compounds of general formula (I) in which R 1 , Y, and R 3 are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of hyperproliferative diseases, in particular of generic name diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：WO2019025562A1
公开(公告)日：2019-02-07
申请号：PCT/EP2018/071039
申请日：2018-08-02
申请人： BAYER AKTIENGESELLSCHAFT , BAYER PHARMA AKTIENGESELLSCHAFT , THE BROAD INSTITUTE, INC. , DANA-FARBER CANCER INSTITUTE, INC.
发明人： ELLERMANN, Manuel , GRADL, Stefan, Nikolaus , KOPITZ, Charlotte, Christine , LANGE, Martin , TERSTEEGEN, Adrian , LIENAU, Philip , HEGELE-HARTUNG, Christa , SÜLZLE, Detlev , LEWIS, Timothy, A. , GREULICH, Heidi , WU, Xiaoyun , MEYERSON, Matthew , BURGIN, Alex
IPC分类号： A61K31/5395 , C07D413/10 , C07D417/10 , C07D491/107 , C07D273/04 , A61P35/00
摘要： The present invention provides dihydrooxydiazinone compounds of general formula (I) : in which R 1 , R 2 , R 3 , and R 4 , are as defined herein, methods of preparing said compounds, intermediate compounds useful for preparing said compounds, pharmaceutical compositions and combinations comprising said compounds and the use of said compounds for manufacturing pharmaceutical compositions for the treatment or prophylaxis of diseases, in particular of hyperproliferative diseases, as a sole agent or in combination with other active ingredients.
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公开(公告)号：WO2003000693A1
公开(公告)日：2003-01-03
申请号：PCT/EP2002/006322
申请日：2002-06-10
申请人： BAYER AKTIENGESELLSCHAFT , ERGÜDEN, Jens, Kerim , BAUSER, Marcus , BURKHARDT, Nils , FLUBACHER, Dietmar , FRIEDL, Arno , GERLACH, Irene , HINZ, Volker , JORK, Reinhard , NAAB, Paul , NIEWÖHNER, Ulrich , REPP, Thorsten, Oliver , SCHLEMMER, Karl-Heinz , STOLTEFUSS, Juergen , BRÜCKNER, David , HENDRIX, Martin , SCHAUSS, Dagmar , TERSTEEGEN, Adrian
发明人： ERGÜDEN, Jens, Kerim , BAUSER, Marcus , BURKHARDT, Nils , FLUBACHER, Dietmar , FRIEDL, Arno , GERLACH, Irene , HINZ, Volker , JORK, Reinhard , NAAB, Paul , NIEWÖHNER, Ulrich , REPP, Thorsten, Oliver , SCHLEMMER, Karl-Heinz , STOLTEFUSS, Juergen , BRÜCKNER, David , HENDRIX, Martin , SCHAUSS, Dagmar , TERSTEEGEN, Adrian
IPC分类号： C07D487/04
CPC分类号： C07D487/04
摘要： Die Erfindung betrifft neue Imidazotriazine der allgemeinen Formel (I), Verfahren zu ihrer Herstellung, und ihre Verwendung zur Herstellung von Arzneimitteln zur Behandlung und/oder Prophylaxe von neurodegenerativen Erkrankungen, insbesondere der Parkinsonschen Krankheit.
摘要翻译： 本发明涉及新的imidazotriazines通式（I）中，其制备方法，以及它们用于制备用于治疗和/或预防神经变性疾病的药物的用途，特别是帕金森氏病的处理。
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公开(公告)号：WO2020127504A1
公开(公告)日：2020-06-25
申请号：PCT/EP2019/085983
申请日：2019-12-18
发明人： RÖHRIG, Susanne , ESSIG, Sebastian , ELLERBROCK, Pascal , ANLAUF, Sonja , NEUBAUER, Thomas , HILLISCH, Alexander , MEIER, Katharina , HEITMEIER, Stefan , TERSTEEGEN, Adrian , SCHÄFER, Martina , STAMPFUSS, Jan , LANG, Dieter , WANG, Hongping , ZOU, Zengqiang , MENG, Xianghai , GERICKE, Kersten, Matthias
IPC分类号： C07D491/044 , A61K31/4353 , A61P9/00
摘要： The invention relates to substituted oxopyridine derivatives and to processes for their preparation, and also to their use for preparing medicaments for the treatment and/or prophylaxis of diseases, in particular vascular disorders, preferably thrombotic or thromboembolic disorders and/or thrombotic or thromboembolic complications.
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