公开(公告)号：WO2016150899A3

公开(公告)日：2016-11-17

申请号：PCT/EP2016056104

申请日：2016-03-21

Applicant: BAYER PHARMA AG ,  DEUTSCHES KREBSFORSCH

Inventor： WILLUDA JÖRG ,  TRAUTWEIN MARK ,  GRITZAN UWE ,  FREIBERG CHRISTOPH ,  DITTMER FRANK ,  SCHÖNFELD DORIAN ,  GLÜCK JULIAN MARIUS ,  BRUDER JESSICA ,  SCHLECKER EVA-MARIA ,  GOLFIER SVEN ,  HOLTON SIMON ,  BECKHOVE PHILIP ,  GE YINGZI

IPC: C07K16/28 ,  A61P35/00

CPC classification number: C07K16/2803 ,  C07K2317/21 ,  C07K2317/24 ,  C07K2317/33 ,  C07K2317/34 ,  C07K2317/565 ,  C07K2317/76 ,  C07K2317/92 ,  C07K2317/94

Abstract: The present disclosure provides recombinant antigen-binding regions and antibodies and functional fragments containing such antigen-binding regions that are specific for human and Macaca fascicularis CEACAM6 (Carcinoembryonic antigen-related cell adhesion molecule 6, CD66c, Non-specific crossreacting antigen, NCA, NCA-50/90), and which do not significantly cross-react with the closely related human CEACAM1, human CEACAM3, and human CEACAM5. The disclosure further provides methods to generate this kind of antibodies. The antibodies, accordingly, can be used to treat cancer and other disorders and conditions associated with expression of the CEACAM6. The disclosure also provides nucleic acid sequences encoding the foregoing antibodies, vectors containing the same, pharmaceutical compositions and kits with instructions for use.

Abstract translation: 本公开提供了重组抗原结合区和包含对人和猕猴属CEACAM6特异性的这种抗原结合区的抗体和功能片段（癌胚抗原相关细胞粘附分子6，CD66c，非特异性交叉反应抗原，NCA，NCA -50/90），并且与密切相关的人类CEACAM1，人类CEACAM3和人类CEACAM5不显着交叉反应。 本公开进一步提供了产生这种抗体的方法。 因此，抗体可用于治疗与CEACAM6表达相关的癌症和其它病症和病症。 本公开还提供了编码前述抗体的核酸序列，含有该抗体的载体，药物组合物和具有使用说明书的试剂盒。