公开(公告)号：WO2021133686A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066131

申请日：2020-12-18

Applicant: BECKMAN COULTER, INC.

Inventor： FERNANDEZ DE CASTRO, Juan ,  GUTIERREZ, William ,  ADELMANN, Martin ,  CANO, Jose ,  STATLER, Eric

IPC: G01N1/30 ,  G01N1/31 ,  G01N15/06 ,  G01N1/38 ,  G01N15/00 ,  G01N15/14 ,  G01N15/0656 ,  G01N2001/386 ,  G01N2015/0069 ,  G01N2015/008 ,  G01N2015/0693 ,  G01N2015/1486 ,  G01N33/56972 ,  G01N35/1016 ,  G01N35/1095 ,  G06T2207/30024 ,  G06T2207/30242 ,  G06T7/0012

Abstract: A sample preparation instrument with an integrated device for estimating a concentration of white blood cells in a specimen is described. The sample preparation instrument receives a specimen for which a sample is to be prepared for analysis. The integrated device can implement an optical method, an electrical resistance method, or a flow cytometry method, for example, to estimate the white blood cell concentration in the specimen. For some types of analysis, a sample volume of the specimen is dependent on the white blood cell concentration. Therefore, the sample preparation instrument can automatically determine and adjust the sample volume of the specimen based on the estimated white blood cell concentration prior to adding additional reagents, such as labeling reagents and/or lytic reagents, to prepare the sample.