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公开(公告)号：WO2023091967A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/079985
申请日：2022-11-16
发明人： GUO, Jason Liwei , MASCHARAK, Shamik , FOSTER, Deshka, S. , NORTON, Jeffrey, A. , LONGAKER, Michael, T.
摘要： Systems and methods for personalized treatment of tumors in accordance with embodiments of the invention are illustrated. One embodiment includes a method for determining prognosis for tumors, including obtaining a histological stain of a tumor, extracting a matrix ultrastructure of the tumor from the histological stain, obtaining an image of the tumor, where the image of the tumor is at sufficient resolution to demarcate individual cells, annotating each cell in the image with the respective cell type, determining cellular interactions between cells in the image based on the annotated cell types, providing the matrix ultrastructure and the cellular interactions to a prognosis model, obtaining an estimated survival time from the prognosis model.
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公开(公告)号：WO2023091961A2
公开(公告)日：2023-05-25
申请号：PCT/US2022/079979
申请日：2022-11-16
申请人： ERISYON INC.
摘要： A method for processing a biomolecule may comprise providing, at a first location, (i) a substrate and (ii) a substrate holder coupled to the substrate. The substrate may comprise the biomolecule coupled thereto. The substrate holder and the substrate may be automatically directed from the first location to a second location different from the first location. At the second location, the biomolecule may be processed to provide a processed biomolecule coupled to the substrate. The processing may comprise labelling the biomolecule to provide a labeled biomolecule.
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公开(公告)号：WO2023091750A1
公开(公告)日：2023-05-25
申请号：PCT/US2022/050567
申请日：2022-11-21
申请人： CORNELL UNIVERSITY
发明人： CIRA, Nathaniel James , TAN, Shenghao , SHIRI, Samira , QAZI, Mohsin Jahan , ALBO, Jon , CHEN, Arnold
摘要： This technology provides a liquid dispensing system with a liquid loading device that can be used to load small volumes of liquid by sliding over or under a surface-patterned substrate, or, alternately, moving the surface-patterned substrate over or under the liquid loading device. The surface-patterned substrate may be a substrate with patterned geometry or wettability. The liquid loading device spatially confines liquid against the surface-patterned substrate and delivers it to intended areas on the surface-patterned substrate. The liquid loading device accomplishes this by maintaining liquid in spatially confined sections, and moving relative to the substrate, by, for example, sliding over it to deposit liquid on the surface-patterned substrate. The liquid loading device utilizes geometry and/or wettability to achieve liquid confinement and delivery to intended areas on the surface-patterned substrate.
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公开(公告)号：WO2023084218A1
公开(公告)日：2023-05-19
申请号：PCT/GB2022/052848
申请日：2022-11-10
发明人： GARDNER, Brian , CARLIN, Scott , CARDONA, Javier , TACHTATZIS, Christos , KANE, Danny , MAGENNIS, Brian , O'DONOGHUE, Ronan
摘要： A system (200) for taking and analysing air samples is presented. The system includes an air sampling unit (210), a sample processing unit (220), an imaging unit (230), and a transport mechanism (240). The air sampling unit receives an air filter cartridge having an air filter and a slide, and to passes a volume of air through the air filter. The sample processing unit (220) applies a solvent onto the air filter to obtain a sample matrix on the slide. The imaging unit (230) obtains an image of the sample matrix. The transport mechanism (240) takes the air filter cartridge and moves it from one unit to another within the system. A processor processes the sample matrix image and calculates a concentration of contaminant particles. An air filter cartridge for use with the system is also presented.
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5.发明申请
公开(公告)号：WO2023007422A1
公开(公告)日：2023-02-02
申请号：PCT/IB2022/056991
申请日：2022-07-28
申请人： TETHIS S.P.A.
发明人： FRANCHI, Gian Martino , CARBONE, Roberta , SCARINCI, Daniele Timothy , LECCARDI, Matteo Bruno , STEPIEN, Grazyna Elzbieta , BERTINI, Claudia
摘要： The present invention relates to an apparatus for the automated processing of a body fluid sample, preferably for analysis of liquid biopsy, configured to obtain one or more informative components of the fluid sample separate and distinct from each other, wherein a first component comprises cellular elements which result to be immobilized on planar supports, wherein a second component comprises suspension sample cells, and wherein a third component comprises the sample liquid fraction and it is preferably contained in a test tube. The invention further relates to a method for preparation of said components implemented by said apparatus.
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公开(公告)号：WO2022212791A1
公开(公告)日：2022-10-06
申请号：PCT/US2022/022957
申请日：2022-03-31
发明人： SUBRAMANIAN, Hariharan , HART, John, W. , SWANSON, Tamara, S. , BLUESTONE, Alexander, L. , HAYES, Margaux , HENNING, Michael , GURBAN, Derek , BOOKER, Nick , MOUSKOS, Nick , HENDERSON, Chester , BARTEL, Rebecca , TURNER, Matthew
摘要： An apparatus for depositing and staining a cellular sample, includes a slide processing module comprising a specimen input port (SIP) dock configured to receive a SIP consumable comprising the cellular sample, and position the SIP consumable such that a spray nozzle of the SIP consumable and an air nozzle of the slide processing module are aligned prior to a deposition operation, and a user interface configured receive an input from a user that configures the deposition operation and a staining operation, and an auxiliary systems module, coupled to the slide processing module, comprising a chassis including a removable storage container configured to hold a plurality of bottles comprising one or more of a reagent, a buffer solution, or an ethanol-based fixative, and an electronics subsystem configured to execute, based on the input from the user, a pre-programmed protocol for the deposition operation and the staining operation.
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公开(公告)号：WO2022178267A2
公开(公告)日：2022-08-25
申请号：PCT/US2022/017006
申请日：2022-02-18
申请人： 10X GENOMICS, INC.
IPC分类号： B01L9/00 , G01N1/31 , G01N35/00 , B01L2200/023 , B01L2200/0689 , B01L2300/043 , B01L2300/045 , B01L2300/047 , B01L2300/0822 , B01L9/52 , G01N1/312 , G01N35/00029
摘要： A substrate holder includes a base configured to receive a substrate; a cover configured to mateably engage with the base, the cover defining an opening formed by inner sidewalls; and a removable insert defining a surface, the removable insert being configured to be received within the opening of the cover. The removable insert includes a gasket; a projection coupled to the gasket; and at least two insert tabs extending from opposite sides of the removable insert, each insert tab being configured to engage with at least one of the inner sidewalls forming the opening of the cover.
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公开(公告)号：WO2022135221A1
公开(公告)日：2022-06-30
申请号：PCT/CN2021/137676
申请日：2021-12-14
申请人： 山东骏腾医疗科技有限公司
摘要： 一种组织切片全自动滴染装置，包括机架（100），固定于机架（100）的转运机构（200）、染色箱（700）、封片箱（400）、晾片箱（500）、烘片箱（600）及射流模块（300），转运机构（200）包括承托架（201）、导轨及驱动装置，驱动装置能够驱动承托架（201）沿导轨上下左右移动至各箱体，组织切片全自动滴染装置能够实现染片-封片-晾片-烤片一体化操作过程，实现组织切片处理过程的完全自动化操作，自动化程度高，操作简单，控制方便，并且减少医护人员接触有毒有害试剂，有效保护医护人员的身体健康。另外，还能够有效避免样本交叉污染，经济环保、便捷高效。
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公开(公告)号：WO2022125070A1
公开(公告)日：2022-06-16
申请号：PCT/US2020/063733
申请日：2020-12-08
发明人： WEAVER, Quinton Buford , CHOY, Si-lam Julius , HADDIX, Seth Stephen , SMITH, Kelly B. , LAHMANN, John Michael
摘要： In one example in accordance with the present disclosure, A sample preparation device is described. The sample preparation device includes a mixing chamber to receive a sample and a mixer disposed within the mixing chamber to mix the sample. The sample preparation device also includes a actuator to transmit a torque to the mixer. A seal separates the mixing chamber from a downstream component and a plunger is disposed within the mixing chamber to direct contents of the mixing chamber to the downstream component.
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公开(公告)号：WO2022085341A1
公开(公告)日：2022-04-28
申请号：PCT/JP2021/033767
申请日：2021-09-14
申请人： ソニーグループ株式会社
摘要： 本技術は、目的細胞の含有割合を高めるための試料調製システムを提供することを目的とする。 本技術は、生体粒子を捕捉する物質が固定された基材を含む生体粒子捕捉モジュールと、前記基材から遊離した生体粒子が回収されるリザーバーと、前記リザーバー内の生体粒子が通流される中空糸膜モジュールと、を備えている試料調製システムを提供する。また、本技術は、生体粒子を捕捉する物質が固定された基材を用いて生体粒子を捕捉する捕捉工程と、前記基材から遊離した生体粒子をリザーバーへ回収する回収工程と、前記リザーバーに回収された生体粒子を中空糸膜モジュールへと通流させる中空糸膜処理工程と、を含む試料調製方法も提供する。
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