公开(公告)号：WO2021146105A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/012657

申请日：2021-01-08

Applicant: BECKMAN COULTER, INC.

Inventor： WALLACH, John, M. ,  MU, Xihai

IPC: G01N27/333 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L3/502 ,  G01N27/283 ,  G01N27/301 ,  G01N27/4035 ,  G01N33/48707 ,  G01N33/84

Abstract: An ion selective electrode ("ISE") assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a single housing. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a cartridge that includes a sample well instead of a sample path.

公开(公告)号：WO2005119267A1

公开(公告)日：2005-12-15

申请号：PCT/US2005/018742

申请日：2005-05-27

Applicant: BECKMAN COULTER, INC. ,  MU, Xihai ,  CERNOSEK, Rose, Mary

Inventor： MU, Xihai ,  CERNOSEK, Rose, Mary

IPC: G01N33/72

CPC classification number: G01N33/728 ,  Y10T436/146666

Abstract: A total bilirubin diazo assay is disclosed in which an acidic solution containing a primary aryl amine is combined directly with a nitrite-containing sample solution at approximately neutral pH, resulting in the in situ generation of a diazo compound in the sample solution. The diazo compound reacts with bilirubin in the sample solution to form a colored reaction product that can be measured.

Abstract translation: 公开了一种总胆红素重氮测定法，其中含有伯芳基胺的酸性溶液在约中性pH下直接与含亚硝酸盐的样品溶液组合，导致样品溶液中原位生成重氮化合物。 重氮化合物与样品溶液中的胆红素反应形成可测量的着色反应产物。

公开(公告)号：WO2021146107A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/012664

申请日：2021-01-08

Applicant: BECKMAN COULTER, INC.

Inventor： WALLACH, John, M. ,  MU, Xihai

IPC: G01N27/28 ,  G01N27/333 ,  G01N27/283 ,  G01N33/48735

Abstract: An ion selective electrode ("ISE") assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion.

公开(公告)号：WO2006026120A1

公开(公告)日：2006-03-09

申请号：PCT/US2005/028752

申请日：2005-08-09

Applicant: BECKMAN COULTER, INC. ,  MU, Xihai

Inventor： MU, Xihai

IPC: G01N27/333

CPC classification number: G01N33/49

Abstract: Measuring chloride ions in a sample solution at acidic pH with a potentiometric silver chloride electrode is disclosed.

Abstract translation: 公开了在酸性pH下用电位计氯化银电极测量样品溶液中的氯离子。