公开(公告)号：WO2022029164A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071743

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping ,  CERUTTI, Mark D. ,  HARRISON, Bern

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a ratio of measured probing potential modulation current signals; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are disclosed.

公开(公告)号：WO2022029161A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071740

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping ,  CERUTTI, Mark D.

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function value and the primary current signal; determining a connection function based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are provided.

公开(公告)号：WO2021194987A1

公开(公告)日：2021-09-30

申请号：PCT/US2021/023518

申请日：2021-03-22

Applicant: NIX, INC.

Inventor： MISHRA, Shawn ,  RITSHER, Kenneth ,  CASS, Meridith Unger

IPC: A61B5/145 ,  A61B5/1468 ,  A61B5/1477 ,  A61B5/00 ,  G01N33/487 ,  A61B10/00 ,  B01L3/00 ,  A61B10/0064 ,  A61B2562/0215 ,  A61B5/01 ,  A61B5/0537 ,  A61B5/14507 ,  A61B5/14517 ,  A61B5/4261 ,  A61B5/4266 ,  A61B5/4875 ,  A61B5/6802 ,  A61B5/681 ,  A61B5/6833 ,  G01N33/48707

Abstract: Methods, systems, and devices are described herein for various embodiments of using a sample analysis system to analyze a sample of bodily fluid from a user to determine parameters associated with the user including states of hydration, dehydration, rehydration, electrolyte loss, wellness, recovery, and the like. In some embodiments, the methods disclosed can be implemented using a device worn by a user, and operatively coupled to a sample analysis system configured to collect a sample of bodily fluid, and measure and analyze the bodily fluid to determine a property of the bodily fluid and/or a physiological/wellness parameter (e.g., degree of hydration, electrolyte losses, perspiration rate, etc.) of the user.

公开(公告)号：WO2022029165A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071744

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A biosensor system is configured to establish a steady-state condition and alternate between the steady-state condition and a non-steady-state condition to determine an analyte concentration. The biosensor system includes an electrode system having at least one working electrode and one counter electrode. The working electrode is covered with an analyte catalyzing layer for converting an analyte into measurable species. A membrane system encompasses the electrode system and comprises an analyte permeable membrane. The membrane has an analyte permeability with lower analyte solubility than an analyte solubility outside the membrane. The membrane is configured to trap a measureable species within the membrane such that a steady-state of the measurable species resulting from the analyte is established near the electrode surface. A bias circuit is configured to apply a potential modulation sequence to the working electrode to cause alternating of steady-state and non-steady-state conditions within the electrode system for analyte concentration determination.

公开(公告)号：WO2021133869A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/066765

申请日：2020-12-23

Applicant: NanoDX, Inc.

Inventor： KHOSRAVI, Farhad ,  BASTABLE, David ,  DRYGA, Sergey, A.

IPC: G01N27/414 ,  G01N27/327 ,  G01N27/416 ,  G01N33/49 ,  G01N33/493 ,  G01N27/04 ,  G01N27/403 ,  G01N33/48707 ,  H01L29/0676

Abstract: Sensors having an advantageous design and methods for fabricating such sensors are generally provided. Some sensors described herein comprise pairs of electrodes having radial symmetry, pairs of nested electrodes, and/or nano wires. Some embodiments relate to fabricating electrodes by methods in which nanowires are deposited from a fluid contacted with a substrate in a manner such that it evaporates and is replenished.

公开(公告)号：WO2022235671A2

公开(公告)日：2022-11-10

申请号：PCT/US2022/027473

申请日：2022-05-03

Applicant: Q-STATE BIOSCIENCES, INC.

Inventor： RYAN, Steven ,  DELANEY-BUSCH, Nathaniel ,  DEMPSEY, Graham T.

IPC: G16B40/20 ,  G06V10/82 ,  G16H30/40 ,  G01N33/48707 ,  G01N33/5032 ,  G06N3/08 ,  G06T2207/10016 ,  G06T2207/10056 ,  G06T2207/20081 ,  G06T2207/20084 ,  G06T2207/30024 ,  G06T7/0012

Abstract: The present invention provides methods and systems using optogenetic assays to identify features in measured neuronal activity that can be used to characterize neural disorders and potential therapeutic treatments.

公开(公告)号：WO2022029162A1

公开(公告)日：2022-02-10

申请号：PCT/EP2021/071741

申请日：2021-08-04

Applicant: ASCENSIA DIABETES CARE HOLDINGS AG

Inventor： WU, Huan-Ping ,  CERUTTI, Mark D.

IPC: A61B5/145 ,  A61B5/1495 ,  A61B2560/0223 ,  A61B5/0002 ,  A61B5/1451 ,  A61B5/14532 ,  A61B5/1486 ,  A61B5/14865 ,  A61B5/6801 ,  A61B5/72 ,  A61B5/7228 ,  G01N33/48707 ,  G01N33/49 ,  G16H40/40 ,  G16H40/67 ,  G16H50/30 ,  G16H50/70

Abstract: A method of determining glucose values during continuous glucose monitoring (CGM) measurements includes providing a CGM device including a sensor, a memory, and a processor; applying a constant voltage potential to the sensor; measuring a primary current signal resulting from the constant voltage potential and storing the measured primary current signal in the memory; applying a probing potential modulation sequence to the sensor; measuring probing potential modulation current signals resulting from the probing potential modulation sequence and storing measured probing potential modulation current signals in the memory; determining an initial glucose concentration based on a conversion function and a measured probing potential modulation current signal; determining a connection function value based on the primary current signal and a plurality of the probing potential modulation current signals; and determining a final glucose concentration based on the initial glucose concentration and the connection function value. Other aspects are disclosed.

公开(公告)号：WO2021146105A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/012657

申请日：2021-01-08

Applicant: BECKMAN COULTER, INC.

Inventor： WALLACH, John, M. ,  MU, Xihai

IPC: G01N27/333 ,  B01L2200/026 ,  B01L2200/0689 ,  B01L2300/0645 ,  B01L2300/0861 ,  B01L3/502 ,  G01N27/283 ,  G01N27/301 ,  G01N27/4035 ,  G01N33/48707 ,  G01N33/84

Abstract: An ion selective electrode ("ISE") assembly may be installed within a sample path of a biological testing system to measure ion concentration within sample fluid flowing through the sample path. A transducer membrane is placed within a housing and positioned to contact the sample path. A threaded portion is advanced into a socket of the housing and forces the membrane against a sealing portion of the sample path to prevent retention of sample fluid within the housing after testing. Sealing may be accomplished without adhesives or sealants and instead relies upon mechanical pressure of the threaded portion. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a single housing. Another implementation includes a reference measuring electrode and several ion measuring electrodes combined into a cartridge that includes a sample well instead of a sample path.

公开(公告)号：WO2021134010A1

公开(公告)日：2021-07-01

申请号：PCT/US2020/067010

申请日：2020-12-24

Applicant: PATEL, Chirag Bihesh ,  BEINAT, Corinne Gaye ,  CHANG, Edwin ,  GAMBHIR, Sanjiv Sam ,  NATARAJAN, Arutselvan ,  THE BOARD OF TRUSTEES OF THE LELAND STANFORD JUNIOR UNIVERSITY

Inventor： PATEL, Chirag Bihesh ,  BEINAT, Corinne Gaye ,  CHANG, Edwin ,  GAMBHIR, Sanjiv Sam ,  NATARAJAN, Arutselvan

IPC: A61K41/00 ,  A61K33/243 ,  A61K51/0459 ,  G01N2203/0008 ,  G01N2800/52 ,  G01N33/48707

Abstract: Viability of cancer cells (e.g., glioblastoma cells) can be reduced by administering mannose to the cancer cells; and applying an alternating electric field with a frequency between 100 and 500 kHz to the cancer cells. Susceptibility to treatment with an alternating electric field can be determined by measuring uptake of a PKM2 probe (e.g., [18F]DASA) before and after treatment with an alternating electric field. Notably, experiments show that the combination of mannose and the alternating electric field produces a synergistic anti-glioblastoma result.