公开(公告)号：WO2013185084A1

公开(公告)日：2013-12-12

申请号：PCT/US2013/044800

申请日：2013-06-07

Applicant: BIOGEN IDEC MA INC. ,  SUNESIS PHARMACEUTICALS, INC.

Inventor： HOPKINS, Brian T. ,  CONLON, Patrick ,  CHAN, Timothy R. ,  JENKINS, Tracy J. ,  CAI, Xiongwei ,  HUMORA, Michael ,  SHI, Xianglin ,  MILLER, Ross A. ,  THOMPSON, Andrew

IPC: A01N43/40 ,  A61K31/435 ,  A61K31/445

CPC classification number: C07D401/14

Abstract: The present invention provides compounds and compositions thereof which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same.

Abstract translation: 本发明提供了可用作Bruton酪氨酸激酶抑制剂的化合物及其组合物，其表现出所需特性。

公开(公告)号：WO2013185082A2

公开(公告)日：2013-12-12

申请号：PCT/US2013/044797

申请日：2013-06-07

Applicant: BIOGEN IDEC MA INC. ,  SUNESIS PHARMACEUTICALS, INC.

Inventor： HOPKINS, Brian, T. ,  CAI, Xiongwei ,  CHAN, Timothy R. ,  CONLON, Patrick ,  HUMORA, Michael ,  JENKINS, Tracy J. ,  MACPHEE, J. Michael ,  SHI, Xianglin ,  MILLER, Ross A. ,  THOMPSON, Andrew

IPC: A61K31/506 ,  C07D401/14

CPC classification number: C07D401/14 ,  C07B2200/13 ,  C07D207/16 ,  C07D207/28 ,  C07D211/56 ,  C07D401/04

Abstract: The present invention provides a compound, solid forms, and compositions thereof, which are useful as inhibitors of Bruton's tyrosine kinase and which exhibit desirable characteristics for the same. The present invention also provides methods of making provided compound and solid forms.

Abstract translation: 本发明提供了一种化合物，固体形式及其组合物，其可用作Bruton酪氨酸激酶的抑制剂，并且其表现出对其的期望特性。 本发明还提供了制备所提供的化合物和固体形式的方法。