公开(公告)号：WO2017106429A3

公开(公告)日：2017-08-17

申请号：PCT/US2016066799

申请日：2016-12-15

Applicant: BOEHRINGER INGELHEIM INT

Inventor： BOSANAC TODD ,  BENTZIEN JOERG ,  BURKE MICHAEL JASON ,  FRYER RYAN MICHAEL ,  LARSON ERIC THOMAS ,  TSCHANTZ MATT AARON ,  MCKIBBEN BRYAN PATRICK ,  MAO WANG ,  SHEN YUE ,  SOLEYMANZADEH FARIBA

IPC: C07D401/14 ,  A61K31/4155 ,  A61K31/4439 ,  A61P37/06 ,  C07D403/14

CPC classification number: C07D403/14 ,  C07D401/14

Abstract: The present invention encompasses compounds of the formula (I) wherein the groups R1, Cy and Y are defined herein, which are suitable for the treatment of diseases related to BTK, and processes for making these compounds, pharmaceutical preparations containing these compounds, and their methods of use.

Abstract translation: 本发明包括式（I）化合物，其中基团R1，Cy和Y在本文中定义，它们适用于治疗与BTK有关的疾病，以及制备这些化合物的方法，含有这些化合物的药物制剂和它们的 使用方法。

公开(公告)号：WO2009149139A8

公开(公告)日：2011-02-24

申请号：PCT/US2009046058

申请日：2009-06-03

Applicant: BOEHRINGER INGELHEIM INT ,  BOEHRINGER INGELHEIM PHARMA ,  BETAGERI RAJASHEKHAR ,  BOSANAC TODD ,  BURKE MICHAEL JASON ,  HARCKEN CHRISTIAN ,  KIM SOOJIN ,  KUZMICH DANIEL ,  LEE THOMAS WAI-HO ,  LI ZHIBIN ,  LIU PINGRONG ,  LORD JOHN ,  RAZAVI HOSSEIN ,  REEVES JONATHAN TIMOTHY ,  THOMSON DAVID

Inventor： BETAGERI RAJASHEKHAR ,  BOSANAC TODD ,  BURKE MICHAEL JASON ,  HARCKEN CHRISTIAN ,  KIM SOOJIN ,  KUZMICH DANIEL ,  LEE THOMAS WAI-HO ,  LI ZHIBIN ,  LIU PINGRONG ,  LORD JOHN ,  RAZAVI HOSSEIN ,  REEVES JONATHAN TIMOTHY ,  THOMSON DAVID

IPC: C07D471/04 ,  A61K31/437 ,  A61P5/44 ,  A61P5/46

CPC classification number: C07D471/04

Abstract: Compounds of Formula I wherein R1, R2, X, and Y are as defined herein, or a tautomer, optical isomer, prodrug, co-crystal, or salt thereof; pharmaceutical compositions containing such compounds, and methods of modulating the glucocorticoid receptor function and methods of treating disease-states or conditions mediated by the glucocorticoid receptor function or characterized by inflammatory, allergic, or proliferative processes in a patient using these compounds.

Abstract translation: 其中R1，R2，X和Y如本文所定义的式I化合物或其互变异构体，旋光异构体，前药，共结晶或其盐; 含有这些化合物的药物组合物，以及调节糖皮质激素受体功能的方法和治疗由糖皮质激素受体功能介导的疾病状态或病症的方法，或其特征在于使用这些化合物的患者的炎症，过敏或增殖过程。

公开(公告)号：WO2008036540A3

公开(公告)日：2008-05-29

申请号：PCT/US2007078343

申请日：2007-09-13

Applicant: BOEHRINGER INGELHEIM INT ,  BOEHRINGER INGELHEIM PHARMA ,  BOSANAC TODD ,  GINN JOHN DAVID ,  HICKEY EUGENE RICHARD ,  KIRRANE THOMAS MARTIN ,  LIU WEIMIN ,  PROKOPOWICZ ANTHONY S ,  SHIH CHENG-KON ,  SNOW ROGER JOHN ,  TURNER MICHAEL ROBERT ,  WU FRANK ,  YOUNG ERICK RICHARD ,  SCHLYER SABINE K

Inventor： BOSANAC TODD ,  GINN JOHN DAVID ,  HICKEY EUGENE RICHARD ,  KIRRANE THOMAS MARTIN ,  LIU WEIMIN ,  PROKOPOWICZ ANTHONY S ,  SHIH CHENG-KON ,  SNOW ROGER JOHN ,  TURNER MICHAEL ROBERT ,  WU FRANK ,  YOUNG ERICK RICHARD ,  SCHLYER SABINE K

IPC: A61K31/472 ,  A61K31/517 ,  A61P9/00

CPC classification number: A61K31/472 ,  A61K31/4725 ,  A61K31/496 ,  A61K31/517 ,  A61K31/5377 ,  A61K31/541 ,  C07D217/24 ,  C07D239/88 ,  C07D239/90 ,  C07D401/12 ,  C07D401/14 ,  C07D403/12 ,  C07D405/12 ,  C07D409/12 ,  C07D413/12 ,  C07D487/08

Abstract: Disclosed are novel substituted 2H-isoquinolin-1-one and 3H-quinazolin-4-one derivatives useful as inhibitors of Rho kinase and for treating a variety of diseases and disorders that are mediated or sustained through the activity of Rho kinase, including cardiovascular diseases, pharmaceutical compositions comprising such compounds, methods for using such compounds and processes for making such compounds.

Abstract translation: 公开了新的取代的2H-异喹啉-1-酮和3H-喹唑啉-4-酮衍生物，其可用作Rho激酶抑制剂并用于治疗通过Rho激酶活性介导或维持的多种疾病和病症，包括心血管疾病 ，包含此类化合物的药物组合物，使用此类化合物的方法和制备此类化合物的方法。