公开(公告)号：WO2021041230A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/047439

申请日：2020-08-21

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： DELANEY, JR., Joseph T. ,  KOLSTE, Kolbein K. ,  DYNDIKOVA, Tatyana

IPC: A61K49/04 ,  C08G65/26 ,  C08G65/332 ,  C08G65/333 ,  C08G65/337 ,  C08K5/16 ,  C08L71/02

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymeric arms, wherein a first portion of the polymeric arms each comprises a reactive end group and wherein a second portion of the polymeric arms each comprises a radiopaque aromatic moiety comprising a monocyclic or multicyclic aromatic structure having a plurality of radiopaque functional groups and a plurality of hydrophilic functional groups. In some aspects, the present disclosure pertains to systems comprising (a) a first composition comprising such a radiopaque polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group. In some aspects, the present disclosure pertains to crosslinked reaction products of (a) such a radiopaque polymer and (b) a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group.

公开(公告)号：WO2021041234A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/047450

申请日：2020-08-21

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： DELANEY, JR., Joseph T. ,  KOLSTE, Kolbein K. ,  DYNDIKOVA, Tatyana

IPC: C08G73/02 ,  A61K31/43 ,  A61K47/69 ,  C08L79/02

Abstract: In some aspects, the present disclosure pertains to a polymer that comprises a plurality of polymer arms, wherein a first portion of the polymer arms comprise a reactive end group and wherein a second portion of the polymer arms comprise a branched end group that comprise a plurality of covalently attached diagnostic and/or therapeutic groups, which may be, for example, radiocontrast groups or radioactive groups. Other aspects pertain to a system that comprises (a) a first composition comprising such a polymer and (b) a second composition comprising a multifunctional compound that comprises reactive functional groups that are reactive with the reactive end group of the multi-arm polymer. Still other aspects pertain to a crosslinked reaction product of (a) such a polymer and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end group of the multi-arm polymer.

公开(公告)号：WO2021041222A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/047428

申请日：2020-08-21

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： DELANEY, JR., Joseph T. ,  GROSSO, Paul V. ,  KUMMAILIL, John ,  DYNDIKOVA, Tatyana ,  REHDER, Carey

IPC: A61K47/56 ,  C08G73/02 ,  C08G83/00 ,  A61K9/00 ,  A61L31/14 ,  C08J3/075 ,  C08J3/24 ,  C08L79/02 ,  C08L101/00

Abstract: In some aspects, the present disclosure pertains to a multi-arm polymer comprising a core and a plurality of polyoxazoline segments (or arms) having a first end that is covalently attached to the core and a second end comprising a moiety that comprises a reactive group. In some aspects, systems are provided that comprise a first composition comprising such a multi-arm polymer and a second composition comprising a multifunctional compound that comprises functional groups that are reactive with the reactive groups of the multi-arm polymer. In some aspects, systems are provided that comprise crosslinked reaction products of such a multi-arm polymer and such a multifunctional compound.

公开(公告)号：WO2021158546A1

公开(公告)日：2021-08-12

申请号：PCT/US2021/016213

申请日：2021-02-02

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： DELANEY, JR., Joseph T. ,  BODEN, Mark W. ,  MURPHY, John ,  MOLNAR, Viktoria ,  DYNDIKOVA, Tatyana ,  ZIPP, Allison ,  KOLSTE, Kolbein K.

IPC: A61L27/18

Abstract: Described herein are injectable in vivo crosslinking materials for use as soft tissue filler comprising (a) a reactive multi-arm polymer that comprises a plurality of hydrophilic polymeric arms, at least a portion of the hydrophilic polymeric arms comprising one or more reactive end groups and (b) a multifunctional compound that comprises functional groups that are reactive with the reactive end groups of the reactive multi-arm polymer. Also described herein are systems and methods that are based on such materials.

公开(公告)号：WO2021041227A1

公开(公告)日：2021-03-04

申请号：PCT/US2020/047436

申请日：2020-08-21

Applicant: BOSTON SCIENTIFIC SCIMED, INC.

Inventor： DELANEY, JR., Joseph T. ,  GROSSO, Paul V. ,  KUMMAILIL, John ,  DYNDIKOVA, Tatyana ,  REHDER, Carey

IPC: C08F226/10 ,  C08F293/00 ,  C08K5/32

Abstract: In some aspects, the present disclosure pertains to multi-arm polymers that comprise a core and a plurality of polymer segments having a first end that is covalently attached to the core and (a) a second end comprising a moiety that comprises a reactive end group, wherein the polymer segments comprise one or more hydrophilic aprotic NMP-polymerizable monomers, and wherein the reactive multi-arm polymer comprises nitroxide radicals or (b) a second end comprising a moiety that comprises an alkoxyamine group, wherein the core is a polyol residue, and wherein the polymer segments comprise one or more NMP-polymerizable monomers. In some aspects, the present disclosure pertains to a multifunctional alkoxyamine molecule comprising a core and a plurality of alkoxyamine groups covalently attached to the core, wherein the core is a polyol residue.