公开(公告)号：WO2016062823A1

公开(公告)日：2016-04-28

申请号：PCT/EP2015/074522

申请日：2015-10-22

申请人： BUTALCO GMBH

发明人： BOLES, Eckhard ,  DIETZ, Heiko ,  FARWICK, Alexander ,  SCHADEWEG, Virginia ,  OREB, Mislav

IPC分类号： C07K14/395 ,  C12N15/81 ,  C12P7/08 ,  C12P7/12

CPC分类号： C07K14/395 ,  C12N1/18 ,  C12N9/1205 ,  C12N9/90 ,  C12N9/92 ,  C12N15/52 ,  C12N15/81 ,  C12N15/905 ,  C12P7/06 ,  C12P7/10 ,  C12P7/12 ,  C12Y207/01016 ,  C12Y207/01017 ,  C12Y501/03004 ,  C12Y503/01003 ,  C12Y503/01005 ,  Y02E50/16

摘要： The present invention relates to polypeptides which are Gal2 variants comprising at least one amino acid substitution at a position corresponding to T354, and optionally further amino acid substitution(s). The present invention further relates to nucleic acid molecules encoding the polypeptides and to host cells containing said nucleic acid molecules. The present invention further relates to a method for the production of bioethanol and/or other bio-based compounds, comprising the expression of said nucleic acid molecules, preferably in said host cells. The present invention also relates to the use of the polypeptides, nucleic acids molecule or host cells for the production of bioethanol and/or other bio-based compounds, and/or for the recombinant fermentation of biomaterial containing pentose(s), preferably D-xylose and/or L-arabinose.

摘要翻译： 本发明涉及多肽，其是在对应于T354的位置包含至少一个氨基酸取代的Gal2变体，以及任选地进一步的氨基酸取代。 本发明还涉及编码多肽的核酸分子和含有所述核酸分子的宿主细胞。 本发明还涉及用于生产生物乙醇和/或其它生物基化合物的方法，其包括优选在所述宿主细胞中表达所述核酸分子。 本发明还涉及多肽，核酸分子或宿主细胞用于生产生物乙醇和/或其他基于生物的化合物和/或用于重组发酵含有戊糖的生物材料，优选D- 木糖和/或L-阿拉伯糖。