公开(公告)号：WO2013082307A1

公开(公告)日：2013-06-06

申请号：PCT/US2012/067110

申请日：2012-11-29

Applicant: C2N DIAGNOSTICS

Inventor： WEST, Tim ,  PAOLETTI, Andrew, Corey

IPC: G01N33/483

CPC classification number: G01N33/6896 ,  G01N33/5308 ,  G01N33/6893 ,  G01N2333/47 ,  G01N2458/15 ,  G01N2560/00 ,  G01N2800/28 ,  G06F19/20

Abstract: The present invention provides methods for measuring the absolute concentration of a biomolecule of interest in a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. Also provided are kits for performing the methods of the invention.

Abstract translation: 本发明提供了测量受试者感兴趣的生物分子的绝对浓度的方法。 这样的生物分子可能涉及一种或多种神经和神经变性疾病或病症。 还提供了一种用于确定治疗剂是否影响衍生的中枢神经系统生物分子的体内代谢的方法。 还提供了用于实施本发明的方法的试剂盒。

公开(公告)号：WO2010065878A1

公开(公告)日：2010-06-10

申请号：PCT/US2009/066810

申请日：2009-12-04

Applicant: C2N DIAGNOSTICS ,  WEST, Tim ,  PAOLETTI, Andrew, Corey

Inventor： WEST, Tim ,  PAOLETTI, Andrew, Corey

IPC: G01N30/72 ,  G01N30/06 ,  G01N33/48

CPC classification number: G01N33/6896 ,  G01N33/537 ,  G01N33/58 ,  G01N2496/00

Abstract: The present invention provides methods for measuring the absolute concentration of a biomolecule of interest in a subject. Such biomolecules may be implicated in one or more neurological and neurodegenerative diseases or disorders. Also provided is a method for determining whether a therapeutic agent affects the in vivo metabolism of a central nervous system derived biomolecule. Also provided are kits for performing the methods of the invention.

Abstract translation: 本发明提供了测量受试者感兴趣的生物分子的绝对浓度的方法。 这样的生物分子可能涉及一种或多种神经和神经变性疾病或病症。 还提供了一种用于确定治疗剂是否影响衍生的中枢神经系统生物分子的体内代谢的方法。 还提供了用于实施本发明的方法的试剂盒。