公开(公告)号：WO2023049710A1

公开(公告)日：2023-03-30

申请号：PCT/US2022/076730

申请日：2022-09-20

申请人： CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： GRADINARU, Viviana ,  CHEN, Xinhong ,  RAVINDRA KUMAR, Sripriya

IPC分类号： C07K14/005 ,  A61K48/00

摘要： Disclosed herein include compositions and kits comprising recombinant adeno-associated viruses (rAAVs) with tropisms to the central nervous system, the peripheral nervous system, and/or the lung, with increased specificity and transduction efficiency. Also described include methods of treating various diseases and conditions using the rAAVs.

公开(公告)号：WO2021025995A1

公开(公告)日：2021-02-11

申请号：PCT/US2020/044487

申请日：2020-07-31

申请人： VOYAGER THERAPEUTICS, INC. ,  CALIFORNIA INSTITUTE OF TECHNOLOGY

发明人： SAH, Dinah Wen-Yee ,  HOU, Jinzhao ,  ADACHI, Kei ,  WANG, Wei ,  CHEN, Qingmin ,  CARROLL SOPER, Jenna ,  REN, Amy ,  REN, Xiao-Qin ,  DEVERMAN, Benjamin E. ,  GRADINARU, Viviana ,  HUANG, Qin ,  RAVINDRA KUMAR, Sripriya

IPC分类号： C12N15/864 ,  C07K14/005 ,  C12N2750/14122 ,  C12N2750/14143 ,  C12N2750/14145

摘要： The disclosure relates to compositions, methods, and processes for the preparation, use, and/or formulation of adeno-associated virus capsid proteins, wherein the capsid proteins comprise targeting peptide inserts for enhanced tropism to a target tissue.