公开(公告)号：WO2014143781A1

公开(公告)日：2014-09-18

申请号：PCT/US2014/027888

申请日：2014-03-14

Applicant: CAMAS INCORPORATED

Inventor： MITTENESS, Bradley, M. ,  PHILLIPS, Connie

IPC: A61K39/395 ,  A61K47/02 ,  A61P31/00

CPC classification number: A61K39/395 ,  A61K9/0012 ,  A61K9/0063 ,  A61K39/39575 ,  A61K39/40 ,  A61K2039/505 ,  C07K16/1203 ,  C07K16/1207 ,  C07K16/1242 ,  C07K16/1275 ,  C07K16/14 ,  C07K2317/11 ,  C07K2317/23

Abstract: The present disclosure relates to methods and compositions administered to the lymphatic tissue of an animal to prevent or reduce the incidence of disease or disease symptoms caused by one or more disease causing entities. Tonsillar compositions can be administered to the lymphatic tissue in the oral/nasal region of the animal and can include avian antibodies from eggs of hens inoculated with one or more target disease causing entities. Treating the lymphatic tissue in the oral/nasal region with the compositions described herein can reduce or prevent the disease causing entities from adhering to the lymphatic tissue resulting in reduced infection rates. The present disclosure also relates to oral compositions that can be used to reduce or eliminate oral pathogens in animals.

Abstract translation: 本公开涉及施用于动物的淋巴组织以防止或减少由一种或多种致病实体引起的疾病或疾病症状的发生率的方法和组合物。 扁桃体组合物可以施用于动物的口腔/鼻部区域中的淋巴组织，并且可以包括接种有一种或多种靶疾病引发实体的母鸡蛋的禽抗体。 用本文所述的组合物治疗口腔/鼻腔中的淋巴组织可以减少或预防引起疾病的实体粘附到淋巴组织，导致感染率降低。 本公开还涉及可用于减少或消除动物体内口腔病原体的口腔组合物。

公开(公告)号：WO2011140550A3

公开(公告)日：2011-11-10

申请号：PCT/US2011/035739

申请日：2011-05-09

Applicant: CAMAS INCORPORATED ,  MITTENESS, Bradley, M. ,  PHILLIPS, Connie

Inventor： MITTENESS, Bradley, M. ,  PHILLIPS, Connie

IPC: A61K39/395 ,  A61K9/12 ,  A61P11/00 ,  A61P31/00

Abstract: A microbial adherence inhibitor in the form of fowl egg antibodies is disclosed, along with the method of making it and methods of using it. The inhibitor functions by substantially preventing the attachment of adherence of colony-forming immunogens in the respiratory tracts of host animals and humans. The inhibitor is made by inoculating female birds with the immunogen, harvesting the eggs which contain antibodies to the immunogen, and separating the yolk and albumin from the shells of the eggs. The yolk and albumin contents are administered to animals or human by distributing the contents directly or introducing the contents entrained in air. The adherence inhibiting material can be formulated for use in a variety of ways such as an oral spray or a nasal spray. These formulations can be effective to prevent or reduce respiratory illnesses in animals and humans.

公开(公告)号：WO2017100289A2

公开(公告)日：2017-06-15

申请号：PCT/US2016/065331

申请日：2016-12-07

Applicant: CAMAS INCORPORATED

Inventor： FAGERLUND, Jeff ,  MITTENESS, Bradley, M. ,  PHILLIPS, Connie

IPC: A61K38/02

CPC classification number: C07K16/00 ,  C07K2317/23 ,  C07K2317/622

Abstract: Neutralizing antibodies through recombinant protein expression were identified by mining antibody repertoires by high-throughput second generation sequencing. Sequencing across the majority of light and heavy chain variable regions of chicken immunoglobulins was performed at two immunological time points: a non-immune (naive) state and a post-hyperimmunization state. The mRNA was extracted from unsorted and unselected PBMC populations and identification of antigen-specific antibody sequences leveraged the significant disparity of abundance of an individual B cell clone in non-immune and immunized states. Through bioinformatic analysis, candidate amino acid sequences for variable heavy chain and light chains were identified. Recombinant polypeptides with the binding domains having the identified amino acid sequences for variable heavy chain and light chains were expressed and screened using immunoassays to confirm antigen-specificity.

公开(公告)号：WO2018236894A1

公开(公告)日：2018-12-27

申请号：PCT/US2018/038317

申请日：2018-06-19

Applicant: CAMAS INCORPORATED

Inventor： MITTENESS, Bradley, M.

IPC: A61K39/40 ,  A61K35/57 ,  A23K50/10 ,  A23K20/147 ,  A23K10/00

Abstract: Compositions for reducing the emission of methane by ruminant animals are disclosed. The compositions include avian antibodies against methanogens generally found in the rumen of the animals. Egg contents of eggs from female birds inoculated with immunogenic compositions containing one or more methanogens or antigens derived from methanogens are used. The antibodies in the egg contents may be used directly without further purification, may be partially purified or purified. The compositions may be administered in drinking water or in animal feed. Administering of the anti-methanogenic composition reduces the emission of methane and increases the efficiency of feed conversion.

公开(公告)号：WO2017100289A3

公开(公告)日：2017-06-15

申请号：PCT/US2016/065331

申请日：2016-12-07

Applicant: CAMAS INCORPORATED

Inventor： FAGERLUND, Jeff ,  MITTENESS, Bradley, M. ,  PHILLIPS, Connie

IPC: A61K38/02 ,  A61K39/00 ,  C12N15/82 ,  C12N15/85

Abstract: Neutralizing antibodies through recombinant protein expression were identified by mining antibody repertoires by high-throughput second generation sequencing. Sequencing across the majority of light and heavy chain variable regions of chicken immunoglobulins was performed at two immunological time points: a non-immune (naive) state and a post-hyperimmunization state. The mRNA was extracted from unsorted and unselected PBMC populations and identification of antigen-specific antibody sequences leveraged the significant disparity of abundance of an individual B cell clone in non-immune and immunized states. Through bioinformatic analysis, candidate amino acid sequences for variable heavy chain and light chains were identified. Recombinant polypeptides with the binding domains having the identified amino acid sequences for variable heavy chain and light chains were expressed and screened using immunoassays to confirm antigen-specificity.

Abstract translation: 通过高通量第二代测序通过挖掘抗体库来鉴定通过重组蛋白表达的中和抗体。 在两个免疫时间点进行鸡免疫球蛋白的大部分轻链和重链可变区的测序：非免疫（天真）状态和超免疫后状态。 从未排序和未选择的PBMC群体中提取mRNA，鉴定抗原特异性抗体序列利用了非免疫和免疫状态下单个B细胞克隆丰度的显着差异。 通过生物信息学分析，鉴定了可变重链和轻链的候选氨基酸序列。 表达具有用于可变重链和轻链的鉴定氨基酸序列的结合结构域的重组多肽，并使用免疫测定法筛选以确认抗原特异性。

公开(公告)号：WO2008088426A2

公开(公告)日：2008-07-24

申请号：PCT/US2007/023166

申请日：2007-11-02

Applicant: CAMAS INCORPORATED ,  NASH, Peter ,  MITTENESS, Bradley, M. ,  O'ROURKE, Michael

Inventor： NASH, Peter ,  MITTENESS, Bradley, M. ,  O'ROURKE, Michael

IPC: A61K39/40

CPC classification number: C07K16/1275 ,  A61K2039/505

Abstract: A method for the production of antibodies or microbial adherents administers is disclosed. The antibodies or microbial adherents inhibitors are administered to a patient suffering from strep throat to substantially prevent the adherents of colony-forming immunogens or haptens in the throat of the patient. Application of the antibodies should decrease the colonization of the oropharynx, and therefore decrease symptoms of the sore inflamed throat and ultimately decrease the need for antibiotics.

Abstract translation: 公开了生产抗体或微生物附着物的方法。 将抗体或微生物附着抑制剂施用于患有链球菌性咽喉炎的患者，以基本上防止患者咽喉中形成集落的免疫原或半抗原的附着物。 抗体的应用应该减少口咽的定居，并且因此减少咽喉炎发炎的症状并且最终减少对抗生素的需要。