公开(公告)号：WO2018231996A1

公开(公告)日：2018-12-20

申请号：PCT/US2018/037350

申请日：2018-06-13

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： TERNES, David J. ,  YU, Yinghong ,  HUMPHREY, Jason ,  PERSCHBACHER, David L. ,  DUFRESNE, Michael James ,  MACEWEN, Adam ,  HERRMANN, Keith L.

IPC: A61N1/368

Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.

公开(公告)号：WO2020123134A1

公开(公告)日：2020-06-18

申请号：PCT/US2019/062997

申请日：2019-11-25

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： AN, Qi ,  YU, Yinghong ,  MACEWEN, Adam

IPC: A61N1/368 ,  A61N1/365 ,  A61B5/0452 ,  A61B5/0245

Abstract: Systems and methods for monitoring and treating patients with heart failure are discussed. The system can store in a memory stimulation parameters, including stimulation timing parameters for a plurality of heart rate ranges. The system includes a plurality of timers with respective durations for the plurality of heart rate ranges. A stimulation control circuit can identify a target heart range in which a detected heart rate falls, and measure an atrioventricular (AV) conduction characteristic value in response to the timer for the target heart range being expired at the detected heart rate. The stimulation control circuit can update a stimulation parameter corresponding to the target heart rate range using the measured AV conduction characteristic. The updated stimulation parameter can be used in cardiac stimulation.

公开(公告)号：WO2018232004A1

公开(公告)日：2018-12-20

申请号：PCT/US2018/037359

申请日：2018-06-13

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： TERNES, David J. ,  YU, Yinghong ,  HUMPHREY, Jason ,  PERSCHBACHER, David L. ,  DUFRESNE, Michael James ,  MACEWEN, Adam ,  HERRMANN, Keith L.

IPC: A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37

Abstract: Systems and methods for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table. A HF therapy may be delivered according to the determined stimulation site, stimulation mode, and the stimulation timing.

公开(公告)号：WO2018231939A1

公开(公告)日：2018-12-20

申请号：PCT/US2018/037269

申请日：2018-06-13

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： TERNES, David J. ,  YU, Yinghong ,  HUMPHREY, Jason ,  PERSCHBACHER, David L. ,  DUFRESNE, Michael James ,  MACEWEN, Adam ,  HERRMANN, Keith L.

IPC: A61N1/362 ,  A61N1/365 ,  A61N1/368 ,  A61N1/37

Abstract: Systems for monitoring and treating patients with heart failure (HF) are discussed. The system may sense cardiac signals, and receives information about patient physiological or functional conditions. A stimulation parameter table that includes recommended values of atrioventricular delay (AVD) or other timing parameters maybe created at a multitude of patient physiological or functional conditions. The system may periodically reassess patient physiological or functional conditions. A therapy programmer circuit may dynamically switch between left ventricular-only pacing and biventricular pacing, or switch between single site pacing and multisite pacing based on the patient condition. The therapy programmer circuit may adjust AVD and other timing parameters using the cardiac signal input and the stored stimulation parameter table.

公开(公告)号：WO2018048992A1

公开(公告)日：2018-03-15

申请号：PCT/US2017/050414

申请日：2017-09-07

Applicant: CARDIAC PACEMAKERS, INC.

Inventor： SIEJKO, Krzysztof Z. ,  BOHN, Derek D. ,  PERSCHBACHER, David L. ,  MACEWEN, Adam ,  SAHA, Sunipa ,  HERRMANN, Keith L.

IPC: A61B5/0456 ,  A61B5/0464 ,  A61B5/0468 ,  A61N1/37 ,  A61N1/39

Abstract: An apparatus includes a cardiac signal sensing circuit configured to generate a sensed cardiac signal representative of electrical cardiac activity of a subject, a buffer memory and a pause detection circuit. The pause detection circuit is configured to: identify ventricular depolarization in the cardiac signal or the sampled cardiac signal; detect a candidate pause episode using the cardiac signal in which delay in ventricular depolarization exceeds a specified delay threshold; identify noise events in a stored cardiac signal; and discard the cardiac signal of the candidate pause episode when a number of noise events satisfies a specified noise event number threshold, otherwise store the cardiac signal of the candidate pause episode as a bradycardia pause episode.

Abstract translation: 一种设备包括：心脏信号感测电路，被配置为生成表示对象的心脏电活动的感测心脏信号，缓冲存储器和暂停检测电路。 暂停检测电路被配置为：识别心脏信号或采样的心脏信号中的心室去极化; 使用其中心室去极化延迟超过指定延迟阈值的心脏信号检测候选暂停发作; 识别存储的心脏信号中的噪声事件; 并且当多个噪声事件满足指定的噪声事件数量阈值时丢弃候选暂停事件的心脏信号，否则将候选暂停事件的心脏信号存储为心动过缓暂停事件。