公开(公告)号：WO2021130638A1

公开(公告)日：2021-07-01

申请号：PCT/IB2020/062229

申请日：2020-12-18

申请人： CARNA BIOSCIENCES, INC. ,  GILEAD SCIENCES, INC.

发明人： SAWA, Masaaki ,  ARAI, Mai ,  NAKAI, Ryoko ,  MATSUMOTO, Hirokazu ,  PUGH, Catherine ,  HU, Eric ,  GUERRERO, Juan ,  JACOBSEN, Jesse ,  MEDLEY, Jonathan William ,  XU, Jie ,  LAD, Latesh ,  PATEL, Leena ,  GRAUPE, Michael ,  ZHU, Qingming ,  HOLMBO, Stephen ,  KOBAYASHI, Tetsuya ,  WATKINS, Will ,  MOAZAMI, Yasamin ,  YEUNG, Suet C. ,  CODELLI, Julian A. ,  WEAVER, Heath A.

IPC分类号： A61P31/12 ,  A61P31/14 ,  A61P31/16 ,  A61P31/18 ,  A61P35/00 ,  A61P35/02 ,  A61P35/04 ,  C07D487/04 ,  C07D519/00 ,  A61K31/519 ,  A61K31/5377 ,  A61K31/55 ,  A61K31/553 ,  A61K31/5415

摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.