-
公开(公告)号：WO2021130638A1
公开(公告)日：2021-07-01
申请号：PCT/IB2020/062229
申请日：2020-12-18
发明人： SAWA, Masaaki , ARAI, Mai , NAKAI, Ryoko , MATSUMOTO, Hirokazu , PUGH, Catherine , HU, Eric , GUERRERO, Juan , JACOBSEN, Jesse , MEDLEY, Jonathan William , XU, Jie , LAD, Latesh , PATEL, Leena , GRAUPE, Michael , ZHU, Qingming , HOLMBO, Stephen , KOBAYASHI, Tetsuya , WATKINS, Will , MOAZAMI, Yasamin , YEUNG, Suet C. , CODELLI, Julian A. , WEAVER, Heath A.
IPC分类号： A61P31/12 , A61P31/14 , A61P31/16 , A61P31/18 , A61P35/00 , A61P35/02 , A61P35/04 , C07D487/04 , C07D519/00 , A61K31/519 , A61K31/5377 , A61K31/55 , A61K31/553 , A61K31/5415
摘要： The present disclosure provides diacylglycerol kinase modulating compounds, and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：WO2022271684A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034321
申请日：2022-06-21
发明人： CODELLI, Julian, A. , GRAUPE, Michael , GUERRERO, Juan, A. , HOLMBO, Stephen, D. , KOBAYASHI, Tetsuya , MOAZAMI, Yasamin , PATEL, Leena, B. , WEAVER, Heath, A. , XU, Jie , YEUNG, Suet, C. , ZHU, QingMing
IPC分类号： C07D487/04 , C07D519/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/519
摘要： The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents formula (I).
-
公开(公告)号：WO2022271677A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034310
申请日：2022-06-21
发明人： GRAUPE, Michael , GUERRERO, Juan A. , HOLMBO, Stephen D. , JACOBSEN, Jesse M. , KOBAYASHI, Tetsuya , PATEL, Leena B. , WEAVER, Heath A. , XU, Jie , YEUNG, Suet C.
IPC分类号： C07D239/95 , C07D401/04 , C07D401/12 , C07D401/14 , C07D403/04 , C07D403/12 , C07D405/12 , C07D413/04 , C07D413/14 , C07D417/12 , C07D471/04 , C07D487/08 , C07B59/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/517 , C07B59/002
摘要： The application relates to diacylglycerol kinase modulating quinazolin-2-one derivatives of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：WO2021096860A1
公开(公告)日：2021-05-20
申请号：PCT/US2020/059837
申请日：2020-11-10
发明人： CHU, Hang , GUERRERO, Juan A. , HURTLEY, Anna E. , JIANG, Lan , KATO, Darryl , KOBAYASHI, Tetsuya , LIN, David W. , MEDLEY, Jonathan William , NADUTHAMBI, Devan , TSUI, Vickie H. , VENKATARAMANI, Chandrasekar , WATKINS, William J. , YANG, Hong , ZHU, QingMing
IPC分类号： A61P35/00 , C07D513/10 , C07D513/20 , C07D513/22 , C07D519/00 , A61K31/553
摘要： The present disclosure generally relates to compounds of Formula (I) and pharmaceutical compositions that may be used in methods of treating cancer.
-
公开(公告)号：WO2022271650A1
公开(公告)日：2022-12-29
申请号：PCT/US2022/034270
申请日：2022-06-21
发明人： CODELLI, Julian A. , GRAUPE, Michael , GUERRERO, Juan A. , JACOBSEN, Jesse M. , KOBAYASHI, Tetsuya , MEDLEY, Jonathan William , MOAZAMI, Yasamin , PATEL, Leena , XU, Jie , YEUNG, Suet C.
IPC分类号： C07D471/14 , C07D487/04 , C07D519/00 , A61P31/18 , A61P31/20 , A61P35/00 , A61P35/04 , A61K31/519
摘要： The application relates to diacylglycerol kinase modulating compounds of the general Formula (I), and pharmaceutical compositions thereof, for treating cancer, including solid tumors, and viral infections, such as HIV or hepatitis B virus infection. The compounds can be used alone or in combination with other agents.
-
公开(公告)号：WO2018039531A1
公开(公告)日：2018-03-01
申请号：PCT/US2017/048565
申请日：2017-08-25
发明人： DU, Jinfa , KAPLAN, Joshua A. , KIRSCHBERG, Thorsten A. , KOBAYASHI, Tetsuya , LAZERWITH, Scott E. , LEE, Rick Andrew , MEDLEY, Jonathan William , MITCHELL, Michael L. , MORGANELLI, Philip Anthony , PYUN, Hyung-Jung , SHEVICK, Sophia L. , SQUIRES, Neil H. , WATKINS, William J.
IPC分类号： C07D487/04 , C07D519/00 , A61K31/407 , A61K31/433 , A61K31/4192 , A61K31/4245 , A61K31/4439
摘要： This application relates to substituted fused pyrrole compounds of formula I, and pharmaceutical compositions comprising them which inhibit HBV replication, and methods of making and using them. Formula (I)
摘要翻译： 本申请涉及式I的取代的稠合吡咯化合物，以及包含它们的抑制HBV复制的药物组合物，以及制备和使用它们的方法。 公式（I）
-
公开(公告)号：WO2014182929A1
公开(公告)日：2014-11-13
申请号：PCT/US2014/037344
申请日：2014-05-08
发明人： AKTOUDIANAKIS, Evangelos , CHIN, Gregory , CORKEY, Britton Kenneth , DU, Jinfa , ELBEL, Kristyna , JIANG, Robert H. , KOBAYASHI, Tetsuya , LEE, Rick , MARTINEZ, Ruben , METOBO, Samuel E. , MISH, Michael , MUNOZ, Manuel , SHEVICK, Sophie , SPERANDIO, David , YANG, Hai , ZABLOCKI, Jeff
IPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , A61K31/422 , A61P35/00
CPC分类号： C07D413/04 , C07D413/14 , C07D417/14 , C07D453/02 , C07D471/04
摘要： This application relates to chemical compounds which may act as inhibitors of, or which may otherwise modulate the activity of, a bromodomain-containing protein, including bromodomain-containing protein 4 (BRD4), and to compositions and formulations containing such compounds, and methods of using and making such compounds. Compounds include compounds of Formula (I) wherein R 1a , R 1b , R 2a , R 2b , R 3 , R 4a , R 4b , and R 5 are described herein.
摘要翻译： 本申请涉及可用作含溴结构域的蛋白质（包括含溴结构域蛋白质的蛋白质4（BRD4））的抑制剂或其它调节活性的化合物，以及含有这些化合物的组合物和制剂，以及 使用和制造这些化合物。 化合物包括其中R1a，R1b，R2a，R2b，R3，R4a，R4b和R5如本文所述的式（I）化合物。
-
公开(公告)号：WO2014008285A1
公开(公告)日：2014-01-09
申请号：PCT/US2013/049119
申请日：2013-07-02
发明人： BJORNSON, Kyla , CANALES, Eda , COTTELL, Jeromy, J. , KARKI, Kapil, Kumar , KATANA, Ashley, Anne , KATO, Darryl , KOBAYASHI, Tetsuya , LINK, John, O. , MARTINEZ, Ruben , PHILLIPS, Barton, W. , PYUN, Hyung-jung , SANGI, Michael , SCHRIER, Adam, James , SIEGEL, Dustin , TAYLOR, James, G. , TRAN, Chinh, Viet , TREJO MARTIN, Teresa, Alejandra , VIVIAN, Randall, W. , YANG, Zheng-Yu , ZABLOCKI, Jeff , ZIPFEL, Sheila
IPC分类号： C07D491/18 , A61P31/14 , A61K31/4995
CPC分类号： A61K31/498 , A61K31/10 , A61K31/401 , A61K31/4745 , A61K31/4985 , A61K31/506 , A61K31/519 , A61K38/00 , A61K38/06 , A61K38/21 , A61K45/06 , C07D241/36 , C07D403/14 , C07D498/16 , C07D498/22 , C07K5/08 , C07K5/0808 , C07K5/0812 , C07K5/0827 , A61K2300/00
摘要： Compounds of Formula I are disclosed, As well as pharmaceutically acceptable salts thereof. Methods of using said compounds and pharmaceutical compositions containing said compounds are also disclosed.
摘要翻译： 公开了式I的化合物，以及其药学上可接受的盐。 还公开了使用所述化合物和含有所述化合物的药物组合物的方法。
-
公开(公告)号：WO2012003392A1
公开(公告)日：2012-01-05
申请号：PCT/US2011/042700
申请日：2011-06-30
申请人： GILEAD SCIENCES, INC. , KOBAYASHI, Tetsuya , KOLTUN, Dmitry , NOTTE, Gregory , PARKHILL, Eric , ZABLOCKI, Jeff
IPC分类号： A61P9/00 , A61P3/10 , C07D471/04 , A61K31/437
CPC分类号： C07D471/04 , C07D519/00
摘要： The present disclosure relates to compounds that are sodium channel inhibitors and to their use in the treatment of various disease states, including cardiovascular diseases and diabetes. In particular embodiments, the structure of the compounds is given by Formula I: wherein R 1 , R 2 , R 3 , R 4 , and R 5 are as described herein, to methods for the preparation and use of the compounds and to pharmaceutical compositions containing the same.
摘要翻译： 本公开涉及作为钠通道抑制剂的化合物及其用于治疗各种疾病状态（包括心血管疾病和糖尿病）的用途。 在具体实施方案中，化合物的结构由式I给出：其中R 1，R 2，R 3，R 4和R 5如本文所述，用于制备和使用化合物的方法以及含有该化合物的药物组合物。
-
公开(公告)号：WO2019222112A1
公开(公告)日：2019-11-21
申请号：PCT/US2019/032053
申请日：2019-05-13
发明人： CHU, Hang , GUERRERO, Juan, A. , HURTLEY, Anna, E. , HWANG, Tae, H. , JIANG, Lan , KATO, Darryl , KOBAYASHI, Tetsuya , KNOX, John, E. , LAZERWITH, Scott, E. , LI, Xiaofen , LIN, David, W. , MEDLEY, Jonathan, W. , MITCHELL, Michael, L. , NADUTHAMBI, Devan , NEWBY, Zachary , SQUIRES, Neil, H. , TSUI, Vickie, H. , VENKATARAMANI, Chandrasekar , WATKINS, William, J. , YANG, Hong
IPC分类号： A61K31/553 , C07D513/08 , A61P35/00
摘要： The present disclosure generally relates to compounds and pharmaceutical compositions that may be used in methods of treating cancer.
-
-
-
-
-
-
-
-
-
搜索结果
14 条记录 (耗时 0.047 秒)
