公开(公告)号：WO2014152091A2

公开(公告)日：2014-09-25

申请号：PCT/US2014/026939

申请日：2014-03-14

Applicant: CARNEGIE INSTITUTION OF WASHINGTON

Inventor： ZHENG, Yixian ,  JIA, Junling ,  ZHENG, Xiaobin

IPC: C12Q1/68

CPC classification number: C12Q1/6806 ,  C12Q2535/113 ,  C12Q2563/149

Abstract: Novel methods of ChlP-seq are disclosed herein. These methods of ChlP-seq employ carrier DNA to prevent loss of DNA samples. The greater DNA yields achieved by this invention permit ChlP-seq of a small number of cells, permitting epigenetic analysis of primary cells of limited quantity.

Abstract translation: 本文公开了ChlP-seq的新方法。 ChlP-seq的这些方法使用载体DNA来防止DNA样品的丢失。 通过本发明获得的更高的DNA产量允许少量细胞的ChIP-seq，允许有限量的原代细胞的表观遗传学分析。

公开(公告)号：WO2017176971A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/026310

申请日：2017-04-06

Applicant: CARNEGIE INSTITUTION OF WASHINGTON

Inventor： ZHENG, Yixian ,  ZHENG, Xiaobin ,  YUE, Sibiao

IPC: C12Q1/68 ,  G06F19/20 ,  G06F19/24

Abstract: Methods of ChlP-seq are disclosed herein. These methods of ChlP-seq employ carrier DNA to prevent loss of DNA samples. The greater DNA yields achieved by the presently disclosed technology permit ChlP-seq of a small number of cells, permitting epigenetic analysis of primary cells of limited quantity.

Abstract translation: 本文公开了ChIP-seq的方法。 ChlP-seq的这些方法使用载体DNA来防止DNA样品的丢失。 通过目前公开的技术获得的更高的DNA产量允许少量细胞的ChIP-seq，允许有限量的原代细胞的表观遗传学分析。

公开(公告)号：WO2017048758A1

公开(公告)日：2017-03-23

申请号：PCT/US2016/051599

申请日：2016-09-14

Applicant: CARNEGIE INSTITUTION OF WASHINGTON

Inventor： ZHENG, Yixian ,  JIA, Junling ,  ZHENG, Xiaobin

IPC: C12Q1/68 ,  G01N33/483

CPC classification number: C12Q1/6806 ,  C12Q2535/113 ,  C12Q2563/149

Abstract: Novel methods of ChlP-seq are disclosed herein. These methods of ChlP-seq employ carrier DNA to prevent loss of DNA samples. The greater DNA yields achieved by this invention permit ChlP-seq of a small number of cells, permitting epigenetic analysis of primary cells of limited quantity.

Abstract translation: 本文公开了ChlP-seq的新方法。 ChlP-seq的这些方法使用载体DNA来防止DNA样品的损失。 通过本发明实现的更大的DNA产量允许少量细胞的ChlP-seq，允许有限量的原代细胞的表观遗传分析。