公开(公告)号：WO1992014420A1

公开(公告)日：1992-09-03

申请号：PCT/US1992001233

申请日：1992-02-14

Applicant: CBS LENS

Inventor： CBS LENS ,  CIVERCHIA, Linda ,  SHEPARD, Dennis, D.

IPC: A61F02/14

CPC classification number: B29D11/00038 ,  A61F2/142 ,  A61F2/145 ,  A61L27/24 ,  A61L27/26 ,  G02B1/043 ,  G02C7/02 ,  A61F2/14 ,  C08L89/06 ,  C08L33/06 ,  C08L89/00

Abstract: A collagen-hydrogel material, artificial lens (60) or contact lens (60) for the eye (40) fabricated from the collagen-hydrogel, which, when affixed to Bowman's membrane (48), promotes and supports epithelial cell growth (52) enabling corneal epithelium, during the healing process, to attach to and cover the lens (60) and to regenerate the stroma (50) which grows over the edge of and attaches to the optical lens (60). The collagen-hydrogel is a hydrogel polymer formed by the free radical polymerization of a hydrophilic monomer solution gelled and crosslinked in the presence of an aqueous stock solution of collagen to form a three dimensional polymeric meshwork for anchoring collagen. The collagen-hydrogel material has a ratio by weight of collagen-to-hydrogel in the range of about .6-to-1000 and less than .6-to-1000 but at a level wherein sufficient collagen is present by weight to at least one of promote epithelial cell growth (52) and regeneration of the stroma (50).

Abstract translation: 胶原 - 水凝胶材料，由胶原 - 水凝胶制成的用于眼睛（40）的人造镜片（60）或隐形眼镜（60），当粘合到鲍曼膜（48）时，其促进和支持上皮细胞生长（52） 使得角膜上皮在愈合过程中能够附着到所述透镜（60）上并覆盖所述透镜（60）并且再生生长在所述光学透镜（60）的边缘上并连接到所述光学透镜（60）的基质（50）。 胶原 - 水凝胶是通过在胶原蛋白原液的存在下凝胶化和交联的亲水性单体溶液的自由基聚合形成的水凝胶聚合物，以形成用于固定胶原的三维聚合物网。 胶原 - 水凝胶材料的胶原蛋白与水凝胶的重量比在约0.6至1000且小于0.6至1000的范围内，但是其中足够的胶原蛋白以重量计至少存在 促进上皮细胞生长（52）和基质再生（50）。

公开(公告)号：WO1988002622A1

公开(公告)日：1988-04-21

申请号：PCT/US1987002645

申请日：1987-10-14

Applicant: CBS LENS

Inventor： CBS LENS ,  CIVERCHIA, Linda ,  SHEPARD, Dennis, D.

IPC: A61F02/14

CPC classification number: A61F2/14 ,  A61F2/145 ,  A61F2/1613 ,  A61F9/00 ,  A61F2220/0008 ,  A61F2310/00365 ,  A61L27/24

Abstract: A method for locating on the cornea an optical lens having a preselected geometric shape and power. The optical lens (60) is formed of a collagen-hydrogel for promoting epithelial cell growth. The optical lens (60) when affixed to Bowman's membrane (40), promotes and supports epithelial cell (52) growth and enables corneal epithelium (42) of the cornea of an eye, during the healing process, to attach to and cover the anterior surface (70) of the lens (60) implanting the same. The collagen-hydrogel is a hydrogel polymer formed by the free radical polymerization of a hydrophilic monomer solution gelled and crosslinked in the presence of an aqueous solution of macromolecules to form a three dimensional polymeric meshwork for anchoring macromolecules. Macromolecules comprising a constituent of a ground substance of tissue, which in the preferred embodiment is a native collagen, are interspersed within the polymeric network forming the hydrogel resulting in a collagen-hydrogel for promoting epithelial cell growth.

Abstract translation: 一种用于在角膜上定位具有预选几何形状和功率的光学透镜的方法。 光学透镜（60）由用于促进上皮细胞生长的胶原 - 水凝胶形成。 光学透镜（60）当固定到鲍曼膜（40）时，促进和支持上皮细胞（52）的生长，并且使愈合过程中角膜的角膜上皮（42）能够附着并覆盖前眼 透镜（60）的表面（70）植入其中。 胶原 - 水凝胶是通过在大分子水溶液存在下凝胶化和交联的亲水性单体溶液的自由基聚合形成的水凝胶聚合物，以形成用于锚定大分子的三维聚合物网。 包含组织研磨物质的组分的大分子在优选实施方案中是天然胶原蛋白，分散在形成水凝胶的聚合物网络内，形成用于促进上皮细胞生长的胶原 - 水凝胶。