公开(公告)号：WO1998020813A1

公开(公告)日：1998-05-22

申请号：PCT/JP1997004076

申请日：1997-11-10

Applicant: MENICON CO., LTD. ,  IKADA, Yoshito ,  OHASHI, Junichi ,  KONDO, Naoki ,  NISHIZAWA, Aoi ,  ANDO, Ichiro

Inventor： MENICON CO., LTD.

IPC: A61F02/14

CPC classification number: A61F2/142

Abstract: An artificial cornea comprising: an optical section having a front face and a back face and made of an optically transparent material; and a supporting section for surrounding at least a part of the optical section to support the same, characterized in that a collar section radially protruded outward from the support section is provided on the support section in its side facing the interior of an eye in the enthesis of the artificial cornea. The artificial cornea can successfully adhere to the eye tissue, prevent the outflow of aqueous humor within the eye and the invasion of bacteria into the eye, and reduce the irritation of eyelid conjunctiva. Further, it can inhibit the progress of downgrowth and causes none of a lowering in transparency of the opical section caused by the downgrowth and lifting or dropout of the artificial cornea from the buried state.

Abstract translation: 一种人造角膜，包括：具有前表面和后表面并由光学透明材料制成的光学部分; 以及用于围绕所述光学部分的至少一部分以支撑所述光学部分的支撑部分，其特征在于，从所述支撑部向外径向突出的凸缘部分设置在所述支撑部分的面向所述构图中的眼睛内部的一侧 的人造角膜。 人造角膜可以成功地粘附在眼组织上，防止眼睛内的房水流出，细菌侵入眼睛，减轻眼睑结膜的刺激。 此外，它可以抑制下生长的进行，并且不会降低由下垂生长引起的眼睑部分的透明性降低，并且使人造角膜从埋藏状态的提升或脱落中降低。

公开(公告)号：WO1995013765A1

公开(公告)日：1995-05-26

申请号：PCT/US1994012898

申请日：1994-11-09

Applicant: OCULEX PHARMACEUTICALS, INC.

Inventor： OCULEX PHARMACEUTICALS, INC. ,  WONG, Vernon, G. ,  KOCHINKE, Frank

IPC: A61F02/14

CPC classification number: A61F9/0017 ,  A61K9/0051

Abstract: Implants comprising active agents are employed for introduction into a suprachoroidal space or an avascular region of an eye for therapeutic purposes. The administration of drugs is controlled and maintained for long periods of time, while ensuring the substantial absence of significant levels outside the site of administration.

Abstract translation: 为了治疗目的，包含活性剂的植入物被用于引入到脉管外空间或眼睛的无血管区域中。 药物的管理长期控制和维持，同时确保在管理现场之外实质上没有显着的水平。

公开(公告)号：WO1994002084A1

公开(公告)日：1994-02-03

申请号：PCT/US1993006533

申请日：1993-07-13

Applicant: SCHACHAR, Ronald, A.

IPC: A61F02/14

CPC classification number: A61F2/14 ,  A61F2/15 ,  A61F9/007 ,  A61F9/00781 ,  A61F2220/0016

Abstract: Presbyopia and hyperopia are treated by increasing the amplitude of accommodation by increasing the effective working distance of the ciliary muscle. To this end, the sclera over the ciliary body is expanded by suturing thereto a relatively rigid band slightly larger than the sclera, surgical alloplasty, or by weakening the sclera by surgery or treatment with enzymes, heat or radiation, which then expands due to intraocular pressure. The scleral expansion band (102) comprises an anterior (108) and posterior (106) rim, and a web (104) extending between the rims. The band may be provided with one or more holes to assist in suturing. The same goal is achieved by shortening the zonules by application of heat or radiation or by surgery. Presbyopia is arrested by inhibiting the continued growth of the crystalline lens by application of heat, radiation or antimitotic drugs to the epithelium of the lens. Primary open angle glaucoma and/or ocular hypertension can be prevented and/or treated by increasing the effective working distance of the ciliary muscle.

Abstract translation: 通过增加睫状肌的有效工作距离来增加调节幅度来治疗老花眼和远视。 为此，将睫状体上的巩膜通过缝合到比巩膜，外科手术成形术稍大的手术或通过用酶，热或辐射的治疗来减弱巩膜的相对刚性的带状物，其随后由于眼内膨胀而膨胀 压力。 巩膜扩张带（102）包括前（108）和后（106）边缘，以及在所述边缘之间延伸的腹板（104）。 带可以设置有一个或多个孔以辅助缝合。 通过应用热或辐射或通过手术缩短分区来实现相同的目标。 通过对镜片的上皮施加热，辐射或抗有丝分裂的药物来抑制晶状体的持续生长来阻止老花眼。 可以通过增加睫状肌的有效工作距离来预防和/或治疗原发性开角型青光眼和/或高眼压症。

公开(公告)号：WO1992014420A1

公开(公告)日：1992-09-03

申请号：PCT/US1992001233

申请日：1992-02-14

Applicant: CBS LENS

Inventor： CBS LENS ,  CIVERCHIA, Linda ,  SHEPARD, Dennis, D.

IPC: A61F02/14

CPC classification number: B29D11/00038 ,  A61F2/142 ,  A61F2/145 ,  A61L27/24 ,  A61L27/26 ,  G02B1/043 ,  G02C7/02 ,  A61F2/14 ,  C08L89/06 ,  C08L33/06 ,  C08L89/00

Abstract: A collagen-hydrogel material, artificial lens (60) or contact lens (60) for the eye (40) fabricated from the collagen-hydrogel, which, when affixed to Bowman's membrane (48), promotes and supports epithelial cell growth (52) enabling corneal epithelium, during the healing process, to attach to and cover the lens (60) and to regenerate the stroma (50) which grows over the edge of and attaches to the optical lens (60). The collagen-hydrogel is a hydrogel polymer formed by the free radical polymerization of a hydrophilic monomer solution gelled and crosslinked in the presence of an aqueous stock solution of collagen to form a three dimensional polymeric meshwork for anchoring collagen. The collagen-hydrogel material has a ratio by weight of collagen-to-hydrogel in the range of about .6-to-1000 and less than .6-to-1000 but at a level wherein sufficient collagen is present by weight to at least one of promote epithelial cell growth (52) and regeneration of the stroma (50).

Abstract translation: 胶原 - 水凝胶材料，由胶原 - 水凝胶制成的用于眼睛（40）的人造镜片（60）或隐形眼镜（60），当粘合到鲍曼膜（48）时，其促进和支持上皮细胞生长（52） 使得角膜上皮在愈合过程中能够附着到所述透镜（60）上并覆盖所述透镜（60）并且再生生长在所述光学透镜（60）的边缘上并连接到所述光学透镜（60）的基质（50）。 胶原 - 水凝胶是通过在胶原蛋白原液的存在下凝胶化和交联的亲水性单体溶液的自由基聚合形成的水凝胶聚合物，以形成用于固定胶原的三维聚合物网。 胶原 - 水凝胶材料的胶原蛋白与水凝胶的重量比在约0.6至1000且小于0.6至1000的范围内，但是其中足够的胶原蛋白以重量计至少存在 促进上皮细胞生长（52）和基质再生（50）。

公开(公告)号：WO1991002499A1

公开(公告)日：1991-03-07

申请号：PCT/US1990004550

申请日：1990-08-13

Applicant: CENTRAL INSTITUTE FOR THE DEAF

Inventor： CENTRAL INSTITUTE FOR THE DEAF ,  SILVERMAN, Martin, S.

IPC: A61F02/14

CPC classification number: A61F2/148 ,  A61B90/00 ,  A61B2017/00969 ,  A61F2/14 ,  A61F9/007 ,  A61L27/20 ,  A61L27/222 ,  A61L27/38 ,  A61L27/3839 ,  A61L2300/414 ,  A61L2300/64 ,  A61L2430/16 ,  A61M2025/0042 ,  C08L5/12

Abstract: Surgical instruments (10, 30), surgical techniques, grafts (63, 50), cell and tissue isolation techniques, and a method for transplanting retinal cells, including photoreceptors (54), retinal pigment epithelium, and choroidea within their normal configuration, or all three tissues in a co-transplantation procedure are provided.

Abstract translation: 手术器械（10,30），手术技术，移植物（63,50），细胞和组织分离技术以及在其正常构型中移植视网膜细胞（包括光感受器）（54），视网膜色素上皮和睫状体的方法，或 提供了共同移植手术中的所有三种组织。

公开(公告)号：WO1989002251A1

公开(公告)日：1989-03-23

申请号：PCT/US1988003020

申请日：1988-09-09

Applicant: NIELSEN, James, McHenry

IPC: A61F02/14

CPC classification number: A61F2/1618

Abstract: Multifocal lenses (1) are formed having a substantially circular central region (22) having a first optical power, surrounded by a plurality of concentric ring regions (24, 26, 28, 30) which alternate between at least two optical powers, one of which may be the first optical power. Preferably, the central region (22) is powered for near vision. For example, one embodiment of the invention is a bifocal lens (1) having a central near-vision portion (22), a first concentric ring region (24) powered for distance vision, and a second concentric ring region (26) having the same power as the central region (22).

公开(公告)号：WO1986002825A1

公开(公告)日：1986-05-22

申请号：PCT/US1985001992

申请日：1985-10-15

Applicant: OMNIS SURGICAL INC.

Inventor： OMNIS SURGICAL INC. ,  VIITALA, Daniel, W.

IPC: A61F02/14

CPC classification number: A61M1/3627 ,  Y10S128/03

Abstract: A venous reservoir in which a blood inlet (42) is located at an inlet end (70) of the container (48) which extends upwardly with a fast rise and for a sufficient distance to allow the blood entering the inlet to enter a large volume and to expand rapidly. The top (74) of the inlet end wall (70) of the container communicates with a vent outlet (46) whereby a sharp decrease in the velocity of the blood flow resulting from its rapid expansion provides buoyancy to air in the blood causing air bubbles to rise to the top of the container and be vented through the vent opening. A top wall (76) of the container extends from the vent opening and toward a blood outlet (44), with the top wall being curved in a manner to prevent the velocity of blood from increasing until the blood is substantially at the blood outlet. The top wall (76) includes a curved portion (80) opposite to the inlet end (70) whereby the air bubbles that have not been discharged immediately upon entering the reservoir may flow back up the top wall to the vent opening.

公开(公告)号：WO1998007391A1

公开(公告)日：1998-02-26

申请号：PCT/US1997014499

申请日：1997-08-14

Applicant: POREX SURGICAL INC.

Inventor： POREX SURGICAL INC. ,  SWORDS, Gregory ,  SHORE, John, W.

IPC: A61F02/14

CPC classification number: A61B17/863 ,  A61B17/8615 ,  A61B17/866 ,  A61F2/141

Abstract: An improved coupling method and device for an ocular prosthesis (23) to a porous polyethylene implant (11) is provided. According to the invention, small surgical screws (19) having a domed head is inserted into a porous plastic implant (11) after the implant has been implanted into an enucleated orbit allowed to vascularize. The domed head projects from the anterior surface of the implant which is covered by conjunctive tissue (17) and is received by a complementary cavity on the rear surface of the ocular prosthesis (23).

Abstract translation: 提供了一种用于眼睛假体（23）到多孔聚乙烯植入物（11）的改进的联接方法和装置。 根据本发明，在将植入物植入被允许血管化的去核轨道之后，将具有穹顶头的小外科用螺钉（19）插入多孔塑料植入物（11）中。 半球形头部从植入物的前表面突出，其由结膜组织（17）覆盖并且被眼假体（23）的后表面上的互补腔容纳。

公开(公告)号：WO1996026690A1

公开(公告)日：1996-09-06

申请号：PCT/US1996003078

申请日：1996-03-04

Applicant: KERAVISION, INC. ,  SILVESTRINI, Thomas, A. ,  MATHIS, Mark, L. ,  SCHOLL, John, A. ,  PROUDFOOT, Robert, A.

Inventor： KERAVISION, INC.

IPC: A61F02/14

CPC classification number: A61F2/147

Abstract: A device (102, 102a, 102b, 102''') for refractive correction of the eye in order to improve the vision of the eye is disclosed. The device is an intrastromal corneal ring where the cone angle "N" ( theta ) is varied according to the desired change in corneal refractive properties. That is, the cone angle is selected to effect a desired change in refractive correction of the eye.

Abstract translation: 公开了一种用于眼睛的屈光矫正以改善眼睛视力的装置（102,102,102b，102“'）。 该装置是根据角膜折射特性的期望变化而改变锥角“N”（θ）的根际角膜环。 也就是说，选择锥角来实现眼睛的屈光矫正的期望变化。

公开(公告)号：WO1996017562A1

公开(公告)日：1996-06-13

申请号：PCT/US1995015821

申请日：1995-12-06

Applicant: SAMIY, Nasrollah ,  GERBER, John, D., T.

IPC: A61F02/14

CPC classification number: A61F2/16 ,  A61F2/142 ,  A61F2009/0043

Abstract: Apparatus and methods are described that project images onto the retina of an eye. The apparatus can include an image memory element (22) for storing an image signal representative of a visual image, a projection element (12) in electrical circuit with the image memory element for generating an optical image signal of the type suitable for detection by a retina and being representative of the visual image, and a focus element (20) that is adapted for implantation into the eye at a position in the eye which is posterior to the cornea and anterior to the retina and that is optically coupled to the projection element (12) for forcussing the optical image onto the retina. The projection element (12) can include a display device (14) that is dimensionally adapted for disposition within the eye at a position posterior to the cornea. The display device (14) can be a liquid crystal display element that has an illuminator element (16) optically coupled to the display device or alternatively can include a laser diode (72) element that optically couples to a scanning mirror that projects light through a damaged cornea.

Abstract translation: 描述了将图像投影到眼睛的视网膜上的装置和方法。 该装置可以包括用于存储表示视觉图像的图像信号的图像存储元件（22），与该图像存储元件电路的电路中的投影元件（12），用于产生适合于检测的类型的光学图像信号 视网膜并且代表视觉图像，以及焦点元件（20），其适于在位于角膜后方且在视网膜前方的眼睛中的位置处植入眼睛并且被光学耦合到投影元件 （12），用于将光学图像调整到视网膜上。 投影元件（12）可以包括显示装置（14），该显示装置尺寸适于在角膜后面的位置处配置在眼睛内。 显示装置（14）可以是具有光学耦合到显示装置的照明元件（16）的液晶显示元件，或者可以包括光学耦合到扫描镜的激光二极管（72）元件，所述扫描镜将投影光通过 损伤的角膜。