公开(公告)号：WO2014165663A1

公开(公告)日：2014-10-09

申请号：PCT/US2014/032804

申请日：2014-04-03

Applicant: CELLULAR DYNAMICS INTERNATIONAL, INC.

Inventor： RAJESH, Deepika ,  BURTON, Sarah, Alice

IPC: C12N5/074 ,  C12N5/071

CPC classification number: C12N5/0676 ,  C12N5/0607 ,  C12N5/0696 ,  C12N2500/02 ,  C12N2500/90 ,  C12N2500/92 ,  C12N2500/98 ,  C12N2501/10 ,  C12N2501/11 ,  C12N2501/115 ,  C12N2501/119 ,  C12N2501/15 ,  C12N2501/155 ,  C12N2501/16 ,  C12N2501/165 ,  C12N2501/33 ,  C12N2501/415 ,  C12N2501/999 ,  C12N2506/45

Abstract: Provided herein are methods for the in vitro differentiation of induced pluripotent stem cells, which have been expanded and/or maintained under defined conditions, into endodermal precursor cells (EPCs) that are capable of producing mono- hormonal beta cells.

Abstract translation: 本文提供了将已经在限定条件下扩增和/或维持的诱导多能干细胞体外分化为能够产生单一激素β细胞的内胚层前体细胞（EPCs）的方法。