公开(公告)号：WO03004655A3

公开(公告)日：2003-10-02

申请号：PCT/FR0202347

申请日：2002-07-04

Applicant: CENTRE NAT RECH SCIENT ,  MAGNALDO THIERRY ,  SARASIN ALAIN

Inventor： MAGNALDO THIERRY ,  SARASIN ALAIN

IPC: A61K35/12 ,  A61K48/00 ,  C07K14/705 ,  C12N5/071 ,  C12N5/074 ,  C12N15/65 ,  C12N5/08 ,  C12N5/10 ,  C12Q1/02 ,  C12Q1/68

CPC classification number: C12N5/0629 ,  A01K2217/075 ,  A61K35/12 ,  A61K48/00 ,  C07K14/70596 ,  C12N5/063 ,  C12N15/65 ,  C12N2501/599 ,  C12N2503/02 ,  C12N2503/04 ,  C12N2510/00 ,  C12N2799/027

Abstract: The invention relates to the use of the CD 24 marker gene in mammals, such as the human CD24 human gene, for the transformation of keratinocyte stem cells when carrying out methods for preparing homogeneous batches of epidermal stem cells transformed in such a way that they contain an exogenous nucleotide sequence of interest, in addition to said transformed keratinocyte stem cells, epidermal tissue reconstituted from said keratinocytes and the uses thereof.

Abstract translation: 本发明涉及当进行用于制备均匀批次的表皮干细胞的方法时，例如人CD24人基因的哺乳动物中的CD 24标记基因用于角化细胞干细胞的转化，所述方法使得它们含有 除了所述转化的角质形成细胞干细胞，从所述角质形成细胞重建的表皮组织及其用途之外，还有一种外源核苷酸序列。