公开(公告)号：WO2007090124A2

公开(公告)日：2007-08-09

申请号：PCT/US2007/061317

申请日：2007-01-30

Applicant: CHANDRASOMA, Parakrama

Inventor： CHANDRASOMA, Parakrama

IPC: C12Q1/68 ,  G01N33/48

CPC classification number: G01N33/57407 ,  G01N33/5064 ,  G01N33/56966 ,  G01N2800/06 ,  G01N2800/062

Abstract: A novel methodology for diagnosing and treating gastroesophageal reflux disease is provided. These methodologies are based on the discovery of a new disease mechanism called hereinafter "reflux carditis", which is a novel mechanistic view of reflux disease that recognizes cardiac mucosa, which has heretofore been regarded as a normal epithelium in the stomach and an abnormal epithelium in the esophagus, as an abnormal mucosa in both the esophagus and stomach.

Abstract translation: 提供了一种用于诊断和治疗胃食管反流病的新方法。 这些方法基于以下称为“回流性心脏炎”的新型疾病机制的发现，该机制是识别心脏粘膜的回流疾病的新颖的机理观点，其迄今被认为是胃中的正常上皮和异常上皮细胞 食管，食管和胃食管异常粘膜。

公开(公告)号：WO2017176990A1

公开(公告)日：2017-10-12

申请号：PCT/US2017/026342

申请日：2017-04-06

Applicant: CHANDRASOMA, Parakrama

Inventor： CHANDRASOMA, Parakrama

IPC: A61B1/273 ,  A61B17/00 ,  G01N33/483

Abstract: Determining the progression of reflux disease in the esophagus of a patient includes identifying the location of an endoscopic gastroesophageal junction in the esophagus, removing a length of tissue of the esophagus that includes a portion of the endoscopic gastroesophageal junction, and identifying the proximal limit of tissue containing cardiac epithelium. Determining the length of the squamo-oxyntic gap of the biopsied tissue can involve measuring the length of tissue extending between the proximal limit of tissue containing gastric oxyntic epithelium to the proximal limit of tissue containing cardiac epithelium. A linear relationship can be determined from a slope of a line extending between a first data point and a second data point that can determine a target age of the patient when the lower esophageal sphincter will have a certain length.

Abstract translation: 确定患者食管中的反流疾病的进展包括确定食道中内窥镜胃食管连接处的位置，移除包括内窥镜胃食管连接处的一部分的一段食管组织 并确定含有心脏上皮的组织的近端极限。 确定活检组织的squamo-oxyntic间隙的长度可以涉及测量在含有胃泌酸上皮的组织的近端界限与包含心脏上皮的组织的近端界限之间延伸的组织的长度。 线性关系可以根据在第一数据点和第二数据点之间延伸的线的斜率来确定，当食管下括约肌将具有特定长度时，该线可以确定患者的目标年龄。