公开(公告)号：WO2011112997A1

公开(公告)日：2011-09-15

申请号：PCT/US2011/028196

申请日：2011-03-11

Applicant: CHEMIC LABORATORIES, INC. ,  JONES, Gerald, S., Jr. ,  ST. LAURENT, Joseph, P. ,  GOODRICH, Scott, A.

Inventor： JONES, Gerald, S., Jr. ,  ST. LAURENT, Joseph, P. ,  GOODRICH, Scott, A.

IPC: A01N37/34 ,  A61K31/275

CPC classification number: C07C69/14 ,  A61K9/0014 ,  A61K9/06 ,  A61K31/22 ,  C07C69/68

Abstract: Described herein are compositions (e.g., a pharmaceutical composition) and compounds of formula I, and their use in the treatment and/or prevention of diseases and disorders.

Abstract translation: 本文描述的是组合物（例如，药物组合物）和式I化合物及其在治疗和/或预防疾病和病症中的用途。

公开(公告)号：WO2019213143A1

公开(公告)日：2019-11-07

申请号：PCT/US2019/030012

申请日：2019-04-30

Applicant: CHEMIC LABORATORIES, INC.

Inventor： JONES, Gerald, S., Jr. ,  ST. LAURENT, Joseph, P. ,  GOODRICH, Scott, A.

IPC: A61K31/05 ,  A61K31/352 ,  A61K47/08

Abstract: The present invention relates to a composition such as an anhydrous gel, comprising a cannabinoid and a silicone-based excipient, methods of administering the composition to a subject, and methods of treatment using said compositions.

公开(公告)号：WO2006044926A2

公开(公告)日：2006-04-27

申请号：PCT/US2005/037504

申请日：2005-10-17

Applicant: CHEMIC LABORATORIES, INC.

Inventor： JONES, Gerald, S., Jr. ,  ST. LAURENT, Joseph, P. ,  GOODRICH, Scott, A.

IPC: C12P7/64 ,  C12P7/62 ,  C07C51/43

CPC classification number: C12P7/6436 ,  C07C67/03 ,  C12P7/62 ,  C07C69/675 ,  C07C69/732 ,  C07C69/68

Abstract: The present invention provides a novel approach for the preparation of fatty alcohol esters of α-hydroxy carboxylic acids. In one form of the invention, the target fatty alcohol ester of α-hydroxy carboxylic acid is produced by converting a lower alkyl ester of α-hydroxy carboxylic acid into a fatty alcohol ester of α-hydroxy carboxylic acid via alcoholysis (i.e., transesterification). The transesterification process is an equilibrium reaction, catalyzed chemically (i.e., with acids or bases) or enzymatically, that is shifted in the desired direction to produce the desired product. One preferred way of shifting the reaction in the direction of the desired product is by reducing the concentration of one of the products (e.g., distillation of a lower-boiling alcohol as soon as it is formed). Another preferred way of shifting the reaction in the direction of the desired product is by increasing the concentration of one of the reactants (e.g., adding more of the starting ester).

Abstract translation: 本发明提供了一种制备α-羟基羧酸的脂肪醇酯的新方法。 在本发明的一种形式中，α-羟基羧酸的目标脂肪醇酯通过醇解（即酯交换）将α-羟基羧酸的低级烷基酯转化为α-羟基羧酸的脂肪醇酯而产生， 。 酯交换方法是平衡反应，在化学上（即酸或碱）或酶促催化，其在所需方向上移动以产生所需产物。 在所需产物的方向上移动反应的一种优选方法是通过降低其中一种产物的浓度（例如，一旦形成低沸点醇即可蒸馏）。 在所需产物的方向上移动反应的另一种优选方法是通过增加一种反应物的浓度（例如，加入更多的起始酯）。

公开(公告)号：WO2007084738A2

公开(公告)日：2007-07-26

申请号：PCT/US2007/001574

申请日：2007-01-22

Applicant: CHEMIC LABORATORIES, INC. ,  JONES, Gerald, S. ,  ST. LAURENT, Joseph, P. ,  GOODRICH, Scott, A. ,  MAGUIRE, George

Inventor： JONES, Gerald, S. ,  ST. LAURENT, Joseph, P. ,  GOODRICH, Scott, A. ,  MAGUIRE, George

IPC: C12P1/00

CPC classification number: C12P17/182 ,  C07D475/04

Abstract: A process for the large-scale chemoenzymatic production of (6S)-5-methyl-5,6,7,8-tetrahydrofolic acid, also known as (6S)-5-methylTHFA, the process comprising the steps of: (1) reducing folic acid (FA) so as to yield dihydrofolic acid (DHFA); (2) stereoselective reducing DHFA with dihydrofolate reductase (DHFR) in the presence of NADP/NADPH, glucose and GluDH so as to yield (6S)-THFA; (3) converting (6S)-THFA to (6S)-5-methylTHFA; and (4) isolating (6S)-5-methylTHFA.

Abstract translation: （6S）-5-甲基-5,6,7,8-四氢叶酸的大规模化学酶生产方法，也称为（6S）-5-甲基THFA，方法 包括以下步骤：（1）减少叶酸（FA）以产生二氢叶酸（DHFA）; （2）在NADP / NADPH，葡萄糖和GluDH存在下用二氢叶酸还原酶（DHFR）立体选择性还原DHFA以产生（6S）-THFA; （3）将（6S）-THFA转化成（6S）-5-甲基THFA; 和（4）分离（6S）-5-甲基THFA。