公开(公告)号：WO2022104136A2

公开(公告)日：2022-05-19

申请号：PCT/US2021/059240

申请日：2021-11-12

申请人： CHILDREN'S MEDICAL CENTER CORPORATION

发明人： STEEN, Judith AJ ,  STEEN, Hanno ,  WESSELING, Hendrik ,  KUMAR, Mukesh ,  MAIR, Waltraud ,  BEEREPOOT, Pieter

IPC分类号： C12Q1/37 ,  G01N30/72 ,  G01N33/68 ,  G01N2333/4709 ,  G01N2440/10 ,  G01N2440/14 ,  G01N2440/36 ,  G01N2800/2821 ,  G01N33/6896

摘要： This disclosure relates to methods for diagnosing and treating a tauopathy, e.g., Alzheimer's disease, in a subject, the methods comprising, in part, identifying one or more post-translation modifications (PTMs) in the subject.

公开(公告)号：WO2023086663A2

公开(公告)日：2023-05-19

申请号：PCT/US2022/049920

申请日：2022-11-15

申请人： THE CHILDREN'S MEDICAL CENTER CORPORATION

发明人： STEEN, Judith AJ ,  STEEN, Hanno ,  CHENG, Long ,  BEEREPOOT, Pieter

IPC分类号： A61K45/06 ,  A61P25/28 ,  G01N33/68

摘要： Provided herein are methods for treating a tauopathy in a subject in need thereof, the method comprising: identifying the subject having a tauopathy; administering to the subject an effective amount of a pharmaceutical composition comprising an agent that decreases the expression and/or activity of immunoproteasome (IP), decreases the expression and/or activity of an immunoproteasome-related protein whose level is upregulated in a subject having tauopathy, increases the expression and/or activity of an immunoproteasome-related protein whose level is downregulated in a subject having tauopathy and increases the expression and/or activity of deubiquitinase while modulating inflammatory cytokine and cytokine receptor expression, thereby treating the tauopathy in the subject.

公开(公告)号：WO2015103594A1

公开(公告)日：2015-07-09

申请号：PCT/US2015/010288

申请日：2015-01-06

申请人： CHILDREN'S MEDICAL CENTER CORPORATION

发明人： BARNABY, Omar S. ,  STEEN, Judith AJ ,  STEVENS, Beth ,  STEEN, Hanno ,  HONG, Soyon Y.

IPC分类号： G01N33/68 ,  G01N33/53

CPC分类号： G01N33/6896 ,  C12Q2600/118 ,  C12Q2600/158 ,  G01N2800/2814 ,  G01N2800/2821 ,  G01N2800/50 ,  G01N2800/60

摘要： The present invention provides CSF protein-based biomarkers and biomarker combinations that are useful in diagnosing dementia or a dementia related neurological disorder a patient. In particular, the biomarkers of this invention are useful to classify a subject sample as Alzheimer's dementia, non-Alzheimer's dementia, as Progressive supranuclear palsy (PSP), non-PSP dementia or normal. In some aspects, the invention relates to methods useful for diagnosing, classifying, and profiling dementia or a dementia related neurological disorder a patient.

摘要翻译： 本发明提供了可用于诊断患者的痴呆或痴呆相关神经障碍的基于CSF蛋白质的生物标志物和生物标志物组合。 特别地，本发明的生物标志物可用于将受试者样品分类为阿尔茨海默氏痴呆，非阿尔茨海默氏痴呆，如进行性核核性麻痹（PSP），非PSP痴呆或正常。 在一些方面，本发明涉及用于诊断，分类和分析患者的痴呆或痴呆相关神经障碍的方法。