公开(公告)号：WO2013103841A1

公开(公告)日：2013-07-11

申请号：PCT/US2013/020316

申请日：2013-01-04

Applicant: CLINICAL REFERENCE LABORATORY, INC.

Inventor： KUNTZ, David, J. ,  HERRERA, Michael, J.

IPC: G01N30/72 ,  G01N30/02 ,  G01N33/483

CPC classification number: G01N33/946 ,  G01N2560/00 ,  Y10T436/173845

Abstract: Methods for the chiral separation and quantitative determination of the d - and l - enantiomers for amphetamine and methamphetamine in bodily fluids and tissues are provided. The method comprises providing a bodily fluid or tissue sample from a subject, extracting target analyte(s) from the sample, followed by eluting on a liquid chromatography column comprising a chiral stationary phase to yield an eluent, which is then analyzed for the presence of the analytes using a mass analyzer.

Abstract translation: 提供了手性分离和定量测定体液和组织中苯丙胺和甲基苯丙胺的d-和l-对映异构体的方法。 该方法包括从受试者提供体液或组织样品，从样品中提取目标分析物，然后在包含手性固定相的液相色谱柱上洗脱以产生洗脱剂，然后分析其中是否存在 使用质谱仪的分析物。