公开(公告)号：WO2022066898A2

公开(公告)日：2022-03-31

申请号：PCT/US2021/051742

申请日：2021-09-23

Applicant: CODIAK BIOSCIENCES, INC.

Inventor： SOOS, Tim ,  NOYES, Aaron ,  DOOLEY, Kevin P. ,  ZHANG, Eric

IPC: A61K39/12 ,  A61K39/215 ,  A61P11/00 ,  A61P31/14 ,  A61K2039/60 ,  A61K2039/62 ,  A61K2039/625 ,  A61K2039/64 ,  C12N2770/20011 ,  C12N2770/20034

Abstract: The present disclosure relates to extracellular vesicles (EVs), e.g., exosomes, which can be rapidly modified to comprise an antigen of interest, and the uses of such EVs as vaccines for the treatment of wide range of diseases or disorders. Also provided herein are methods for preparing and manufacturing such EVs for use as vaccines.

公开(公告)号：WO2021184017A1

公开(公告)日：2021-09-16

申请号：PCT/US2021/022420

申请日：2021-03-15

Applicant: CODIAK BIOSCIENCES, INC.

Inventor： VERMA, Ajay ,  SOOS, Tim ,  ROSS, Nikki ,  MCCOY, Christine ,  FINN, Jonathan ,  SATHYANARAYANAN, Sriram ,  PATEL, Shailendra ,  XU, Ke ,  MCCONNELL, Russell E. ,  DOOLEY, Kevin P.

IPC: A61K39/00 ,  A61P25/28 ,  C07K17/02

Abstract: The present disclosure relates to extracellular vesicles (EVs) that are capable of targeting a cell in the CNS of a subject. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders of the CNS (e.g., neurological disorders).

公开(公告)号：WO2021146616A1

公开(公告)日：2021-07-22

申请号：PCT/US2021/013722

申请日：2021-01-15

Applicant: CODIAK BIOSCIENCES, INC.

Inventor： DOOLEY, Kevin P. ,  SULENTIC, Aaron J. ,  MARTIN, Shelly A. ,  LECHNER, David ,  PIARD, Charlotte M. ,  YEE, Joon Chong ,  ALBERS, Leila

IPC: G01N33/53

Abstract: Provided herein are methods of quantifying extracellular vesicle concentration, such as exosomes, by measuring cholesterol content in a sample. Also provided are methods of processing extracellular vesicles to remove non-exosomal species which contain cholesterol.

公开(公告)号：WO2021248133A1

公开(公告)日：2021-12-09

申请号：PCT/US2021/036234

申请日：2021-06-07

Applicant: CODIAK BIOSCIENCES, INC. ,  VERMA, Ajay ,  GAYDUKOV, Leonid

Inventor： XU, Ke ,  DOOLEY, Kevin P. ,  FINN, Jonathan

IPC: A61K31/00 ,  A61K35/12 ,  C07D417/10 ,  A61K31/713 ,  A61K45/06 ,  C07K17/00

Abstract: The present disclosure relates extracellular vesicles, e.g., exosomes, comprising an antigen-binding moeity, e.g., a single-domain antigen-binding moeity, e.g., a vNAR, a VHH, or a fragment thereof, that specifically binds transferrin receptor, and methods of making and using the same.

公开(公告)号：WO2020163366A1

公开(公告)日：2020-08-13

申请号：PCT/US2020/016625

申请日：2020-02-04

Applicant: CODIAK BIOSCIENCES, INC.

Inventor： DOOLEY, Kevin P. ,  WILLIAMS, Douglas E.

IPC: A61K38/17 ,  A61K39/00 ,  A61P35/04 ,  C07K16/28

Abstract: The present disclosure provides a therapeutic method of treating cancer metastasis by inducing clearance of EVs using a binding agent specific to an EV protein. The method utilizes one or more binding agents specific to EV proteins, where the EV proteins are selected from prostaglandin F2 receptor negative regulator (PTGFRN); basigin (BSG); immunoglobulin superfamily member 2 (IGSF2); immunoglobulin superfamily member 3 (IGSF3); immunoglobulin superfamily member 8 (IGSF8); integrin beta-1 (ITGB1); integrin alpha-4 (ITGA4); 4F2 cell-surface antigen heavy chain (SLC3A2); a class of ATP transporter proteins (ATP1A1, ATP1A2, ATP1A3, ATP1A4, ATP1B3, ATP2B1, ATP2B2, ATP2B3, ATP2B4); CD13 (aminopeptidase N); MME (neprilysin), ENPP1 (ectonucleotide pyrophosphatase/ phosphodiesterase family member 1); and NRP1 (neuropilin-1). Further provided herein includes a pharmaceutical composition for the treatment of cancer metastasis.

公开(公告)号：WO2021189047A2

公开(公告)日：2021-09-23

申请号：PCT/US2021/023485

申请日：2021-03-22

Applicant: CODIAK BIOSCIENCES, INC.

Inventor： SATHYANARAYANAN, Sriram ,  SOOS, Tim ,  XU, Ke ,  NOYES, Aaron ,  DOOLEY, Kevin P. ,  ZHANG, Eric ,  MCCOY, Christine ,  FINN, Jonathan

IPC: C07K14/705 ,  C12N15/62 ,  A61K39/39 ,  A61K9/127 ,  A61K31/7084 ,  A61K39/00 ,  A61K47/69 ,  A61K45/00 ,  A61P31/00 ,  A61P33/02 ,  A61P35/00 ,  A61P31/12 ,  A61K39/215 ,  A61P31/14 ,  A61K2039/555 ,  A61K2039/55555 ,  A61K2039/70 ,  C12N2770/20034 ,  C12N2770/20071

Abstract: The present disclosure relates to extracellular vesicles comprising one or more antigens from a coronavirus (e.g., SARS-CoV-1 or SARS-CoV-2) and optionally an adjuvant. Also provided herein are methods for producing the EVs and methods for using the EVs to treat and/or prevent diseases or disorders, e.g., infectious diseases.

公开(公告)号：WO2020163370A1

公开(公告)日：2020-08-13

申请号：PCT/US2020/016629

申请日：2020-02-04

Applicant: CODIAK BIOSCIENCES, INC.

Inventor： DOOLEY, Kevin P. ,  WILLIAMS, Douglas E. ,  THORNTON, James E.

IPC: C12N15/88 ,  A61K35/12 ,  A61K38/00 ,  A61K9/127 ,  C12N9/48

Abstract: The present disclosure relates to heterologous exosomal vesicle proteins (HEVPs), engineered exosomes comprising HEVPs, and methods of preparing and using these compositions, including therapeutic applications.