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公开(公告)号:WO2014169336A1
公开(公告)日:2014-10-23
申请号:PCT/AU2014/000435
申请日:2014-04-16
Inventor: TROWELL, Stephen , ANDERSON, Alisha , TEHSEEN, Muhammed , DUMANCIC, Mira , BRIGGS, Lyndall , WANG, Jian
IPC: C12Q1/02 , C07K14/705 , C40B40/02 , G01N33/566 , G01N33/22 , C12N15/81
CPC classification number: C12N15/81 , C07K14/43545 , C07K14/705 , C12Q1/025 , G01N33/56961 , G01N33/64 , G01N33/74 , G01N2333/4353 , G01N2333/43534 , G01N2333/726
Abstract: The present invention relates to a yeast cell expressing a nematode G protein coupled receptor (GPCR), whereby ligand binding to the GPCR results in a detectable signal. In particular, the present invention relates to a yeast library expressing a range of different GPCRs, and to methods of screening said library.
Abstract translation: 本发明涉及表达线虫G蛋白偶联受体(GPCR)的酵母细胞,其中与GPCR结合的配体产生可检测的信号。 特别地,本发明涉及表达一系列不同GPCR的酵母文库,以及筛选所述文库的方法。