公开(公告)号：WO2019226617A1

公开(公告)日：2019-11-28

申请号：PCT/US2019/033255

申请日：2019-05-21

申请人： COMPASS THERAPEUTICS LLC

发明人： WATKINS, Jennifer ,  SCHMIDT, Michael March ,  DRAGHI, Monia ,  OLIPHANT, Amanda Frank ,  HALMOS, Sara Marie ,  SCHUETZ, Thomas Joseph ,  LAJOIE, Jason Michael ,  NELSON, Allison

IPC分类号： C07K16/28 ,  C07K16/30 ,  C07K16/32 ,  A61P37/06 ,  A61P35/00 ,  A61P35/02

摘要： The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells ( e.g. , cancer cells) having a low level of expression of the tumor antigen.