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公开(公告)号：WO2020205504A1
公开(公告)日：2020-10-08
申请号：PCT/US2020/025189
申请日：2020-03-27
摘要： The present disclosure provides methods of generating multispecific antigen-binding molecules comprising a common light chain compatible with two or more different heavy chains. The present disclosure further provides methods of identifying common light chains that are compatible with two or more different heavy chains
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公开(公告)号：WO2019226658A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033325
申请日：2019-05-21
摘要： The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize a tumor antigen and CD226.
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公开(公告)号：WO2019226617A1
公开(公告)日：2019-11-28
申请号：PCT/US2019/033255
申请日：2019-05-21
发明人： WATKINS, Jennifer , SCHMIDT, Michael March , DRAGHI, Monia , OLIPHANT, Amanda Frank , HALMOS, Sara Marie , SCHUETZ, Thomas Joseph , LAJOIE, Jason Michael , NELSON, Allison
摘要： The present disclosure provides immunotherapeutic compositions and methods for enhancing an immune response and for treating cancer or inflammatory conditions mediated by autoreactive B cells in a subject. In some aspects, multispecific antigen-binding constructs are provided that recognize at least one tumor antigen or B-lineage cell antigen and NKp30 and/or another activating NK receptor. In some aspects, multispecific antigen-binding constructs are provided that recognize at least two tumor antigens or two antigens expressed by B-lineage cells, NKp30, and another activating NK receptor. The multispecific antigen-binding constructs and methods disclosed herein can be used for the treatment of cancer, even a cancer characterized by a CD16 deficient microenvironment and/or characterized by target cells ( e.g. , cancer cells) having a low level of expression of the tumor antigen.
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