公开(公告)号：WO2018191594A1

公开(公告)日：2018-10-18

申请号：PCT/US2018/027454

申请日：2018-04-13

Applicant: CORNELL UNIVERSITY

Inventor： TUNG, Ching-Hsuan ,  HAN, Myung Shin

IPC: A61K31/00 ,  A61K31/185 ,  A61K31/222 ,  C07D311/02 ,  C07D311/04 ,  C07D311/08

CPC classification number: A61K31/352 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0073 ,  C07D311/82

Abstract: A method for treating a condition characterized by excessive adipose tissue in a subject, the method comprising administering to said subject a compound that inhibits adipogenesis and/or induces adipocyte apoptosis in said excessive adipose tissue, said compound having the structure : (1) wherein: X 1 , X 2 , X 3 , and X 4 are each independently selected from iodine and bromine atoms; X 5 , X 6 , X 7 , and X 8 are each independently selected from hydrogen atom, chlorine, bromine, and iodine atoms; Y 1 is an -O-, -NR'-, or -CR' 2 - linker, wherein R' is independently selected from hydrogen atom and methyl; Z is a hydrocarbon linking group containing 1-12 carbon atoms; R 1 is selected from hydrogen atom, methyl, -OH, and -OR groups, wherein R is an alkyl group containing one to three carbon atoms; and wherein said Formula (1) includes pharmaceutically acceptable salts and solvates of the compounds embraced by Formula (1).