公开(公告)号：WO2018191594A1

公开(公告)日：2018-10-18

申请号：PCT/US2018/027454

申请日：2018-04-13

Applicant: CORNELL UNIVERSITY

Inventor： TUNG, Ching-Hsuan ,  HAN, Myung Shin

IPC: A61K31/00 ,  A61K31/185 ,  A61K31/222 ,  C07D311/02 ,  C07D311/04 ,  C07D311/08

CPC classification number: A61K31/352 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0073 ,  C07D311/82

Abstract: A method for treating a condition characterized by excessive adipose tissue in a subject, the method comprising administering to said subject a compound that inhibits adipogenesis and/or induces adipocyte apoptosis in said excessive adipose tissue, said compound having the structure : (1) wherein: X 1 , X 2 , X 3 , and X 4 are each independently selected from iodine and bromine atoms; X 5 , X 6 , X 7 , and X 8 are each independently selected from hydrogen atom, chlorine, bromine, and iodine atoms; Y 1 is an -O-, -NR'-, or -CR' 2 - linker, wherein R' is independently selected from hydrogen atom and methyl; Z is a hydrocarbon linking group containing 1-12 carbon atoms; R 1 is selected from hydrogen atom, methyl, -OH, and -OR groups, wherein R is an alkyl group containing one to three carbon atoms; and wherein said Formula (1) includes pharmaceutically acceptable salts and solvates of the compounds embraced by Formula (1).

公开(公告)号：WO2015109300A1

公开(公告)日：2015-07-23

申请号：PCT/US2015/011989

申请日：2015-01-20

Applicant: GUIDED THERAPY SYSTEMS, LLC

Inventor： SLAYTON, Michael, H. ,  JAEGER, Paul

IPC: A61N7/00 ,  A61N7/02

CPC classification number: A61N7/02 ,  A61B17/225 ,  A61B17/50 ,  A61H23/008 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0013 ,  A61N2007/0017 ,  A61N2007/0034 ,  A61N2007/0073

Abstract: A system and method for controlling acoustic energy deposition in various media or objects are disclosed. The system and method can generate an acousto-mechanical or acousto-elastic effect in the various media or objects. The acousto-mechanical or acousto-elastic effect can induce a fragmentation of the media or objects.

Abstract translation: 公开了一种用于控制各种介质或物体中的声能沉积的系统和方法。 该系统和方法可以在各种介质或物体中产生声 - 机械或声弹性效应。 声 - 机械或声弹性效应可以引起介质或物体的碎裂。

公开(公告)号：WO2014097288A3

公开(公告)日：2014-09-25

申请号：PCT/IL2013000094

申请日：2013-12-19

Applicant: SYNERON MEDICAL LTD

Inventor： ECKHOUSE SHIMON ,  ROSENBERG AVNER

IPC: A61H7/00

CPC classification number: A61H9/0057 ,  A61B18/12 ,  A61B2018/00291 ,  A61B2018/00452 ,  A61B2018/00464 ,  A61H7/008 ,  A61H23/0245 ,  A61H2201/0207 ,  A61H2201/0292 ,  A61H2201/10 ,  A61H2201/1666 ,  A61H2201/1673 ,  A61H2201/5002 ,  A61H2201/5046 ,  A61H2201/5064 ,  A61H2230/505 ,  A61N1/0476 ,  A61N1/322 ,  A61N1/328 ,  A61N5/022 ,  A61N5/0616 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0034 ,  A61N2007/0078

Abstract: Apparatus comprising an array of individually controlled skin treatment units to be applied to a skin segment with each of the units comprising a housing defining a cavity that fluidly communicates with a source of vacuum pressure having an inner side terminated by a rim facilitating sealing of the cavity when the unit is applied to the skin, dimensions of the cavity being sufficient to accommodate a volume of a skin segment drawn into the cavity by the source of vacuum pressure to create a skin protrusion.

Abstract translation: 一种装置，包括一组单独控制的皮肤治疗单元，其被应用于皮肤区段，其中每个单元包括限定空腔的壳体，所述壳体与真空压力源流体连通，所述腔体具有由边缘封闭的内侧， 当单元被施加到皮肤上时，空腔的尺寸足以容纳通过真空压力源吸入空腔中的一定体积的皮肤部分，以产生皮肤突起。

公开(公告)号：WO2013180554A2

公开(公告)日：2013-12-05

申请号：PCT/KR2013/004888

申请日：2013-06-03

Applicant: 노슨(NOHSN) ,  한철민

Inventor： 한철민

IPC: A61N7/02 ,  A61B8/14 ,  A61M1/00 ,  A61B17/50 ,  A61B5/01

CPC classification number: A61B5/01 ,  A61B8/0858 ,  A61B8/5223 ,  A61M1/00 ,  A61M2202/08 ,  A61N7/02 ,  A61N2007/0008

公开(公告)号：WO2011117869A1

公开(公告)日：2011-09-29

申请号：PCT/IL2011/000271

申请日：2011-03-23

Applicant: REAL AESTHETICS LTD. ,  FEFERBERG, Ilan

Inventor： FEFERBERG, Ilan

IPC: A61N7/00 ,  A61N1/18 ,  A61H15/00

CPC classification number: A61N7/00 ,  A61H7/007 ,  A61H15/00 ,  A61H23/0236 ,  A61H2201/0153 ,  A61H2201/0207 ,  A61H2201/10 ,  A61H2201/1261 ,  A61H2201/165 ,  A61H2201/5092 ,  A61H2205/04 ,  A61H2205/06 ,  A61H2205/081 ,  A61H2205/083 ,  A61H2205/086 ,  A61H2205/108 ,  A61H2207/00 ,  A61H2230/70 ,  A61H2230/80 ,  A61H2230/85 ,  A61N1/18 ,  A61N1/32 ,  A61N2007/0008 ,  A61N2007/0073 ,  A63B21/06 ,  A63B22/0056 ,  A63B22/0235 ,  A63B22/0605 ,  A63B22/0664 ,  A63B2022/0652 ,  A63B2213/00 ,  A63B2213/004 ,  A63B2220/806 ,  A63B2230/01 ,  A63B2230/70

Abstract: System and method for reducing stored body fats in a treatment region on a body. The system includes an ultrasound apparatus, for transmitting ultrasound waves at the treatment region. The ultrasound waves facilitate the release of triglycerides, fat molecules and toxins from stored fat within the treatment region, achieving the reduction of stored body fats by accelerating the relative proportion of fat catabolism in the treatment region. The treated person may be undergoing a physical exercise substantially concurrently to the ultrasound transmission. Electrical stimulation, such as interferential stimulation, may be applied to the treatment region substantially concurrently to the ultrasound transmission. Pressure may be exerted onto the treatment region substantially concurrently to the ultrasound transmission, such as by kneading a portion of the ultrasound apparatus against the treatment region, or by massaging the treatment region, manually or mechanically with a massaging device.

Abstract translation: 用于减少身体处理区域中储存的身体脂肪的系统和方法。 该系统包括用于在治疗区域发射超声波的超声装置。 超声波有助于甘油三酸酯，脂肪分子和毒素从处理区域内储存的脂肪释放，通过加速处理区域脂肪分解代谢的相对比例来实现储存的脂肪的减少。 受治疗者可能正在与超声波传播基本同时进行体育锻炼。 电刺激（例如干扰刺激）可以与超声波传输基本同时地施加到治疗区域。 压力可以基本上与超声波传播相同地施加到治疗区域上，例如通过将一部分超声波装置与处理区域混合，或者通过用按摩装置手动或机械地按摩治疗区域。

公开(公告)号：WO2011089270A1

公开(公告)日：2011-07-28

申请号：PCT/EP2011/050992

申请日：2011-01-25

Applicant: SWITECH MEDICAL AG ,  VOSS, Axel

Inventor： VOSS, Axel

IPC: A61B18/00 ,  A61N7/00

CPC classification number: A61N7/02 ,  A61B2018/00988 ,  A61B2090/0803 ,  A61N2007/0008

Abstract: The application pertains to a medical device (1) including a treatment unit (4) for treating patients, an activation device (3) for activating the treatment unit, and an input device (2) for entering an activation code, the input device being coupled to the activation device (3), and the activation device (3) is arranged to activate the treatment unit (4) for a limited number of treatments and/or for a limited period when a predetermined activation code is entered via the input device (2).

Abstract translation: 该应用涉及包括用于治疗患者的治疗单元（4），用于激活治疗单元的激活装置（3）和用于输入激活码的输入装置（2）的医疗装置（1），所述输入装置 耦合到所述激活装置（3），并且所述激活装置（3）被布置成在经由所述输入装置输入预定的激活代码时，对所述治疗单元（4）进行有限数量的治疗和/或限定的期间 （2）。

公开(公告)号：WO2011041239A1

公开(公告)日：2011-04-07

申请号：PCT/US2010/050280

申请日：2010-09-24

Applicant: MEDICIS TECHNOLOGIES CORPORATION ,  WING, Gregory T. ,  KENNEY, Martin ,  LITTLE, Blake W. ,  FIX, Richard L.

Inventor： WING, Gregory T. ,  KENNEY, Martin ,  LITTLE, Blake W. ,  FIX, Richard L.

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B8/4405 ,  A61B8/546 ,  A61B8/56 ,  A61B2017/0046 ,  A61B2017/00482 ,  A61B2034/101 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0078 ,  A61N2007/0082 ,  B01D19/0042

Abstract: A medical ultrasound system. A base unit is included having system electronics, a user interface and ultrasound control electronics. An ultrasound therapy head is in electronic communication with the base unit. The therapy head includes a replaceable, sealed transducer cartridge with a coupling fluid therein. A cooling system is provided for cooling the coupling fluid. A plurality of guide indicators are positioned around the therapy head to align with crossed lines on a patient so as to properly align the therapy head prior to use. The therapy head can provide variable treatments to an area while the therapy head is in contact with a patient.

Abstract translation: 医疗超声系统 包括系统电子设备，用户界面和超声波控制电子设备的基本单元。 超声治疗头与基本单元电子通信。 治疗头包括其中具有耦合流体的可更换密封的换能器筒。 提供冷却系统以冷却耦合流体。 多个引导指示器围绕治疗头定位以与患者上的交叉线对准，以便在使用之前使治疗头正确对准。 治疗头可以在治疗头与患者接触时向区域提供可变治疗。

公开(公告)号：WO2011041235A1

公开(公告)日：2011-04-07

申请号：PCT/US2010/050267

申请日：2010-09-24

Applicant: MEDICIS TECHNOLOGIES CORPORATION ,  BOCKENSTEDT, Craig R. ,  CRUNKILTON, Jeffrey R. ,  WING, Gregory T. ,  BENNETT, Frederick J. ,  LITTLE, Blake W.

Inventor： BOCKENSTEDT, Craig R. ,  CRUNKILTON, Jeffrey R. ,  WING, Gregory T. ,  BENNETT, Frederick J. ,  LITTLE, Blake W.

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B8/4405 ,  A61B8/546 ,  A61B8/56 ,  A61B2017/0046 ,  A61B2017/00482 ,  A61B2034/101 ,  A61N7/00 ,  A61N2007/0008 ,  A61N2007/0078 ,  A61N2007/0082 ,  B01D19/0042

Abstract: A medical ultrasound system. A base unit is included having system electronics, a user interface and ultrasound control electronics. An ultrasound therapy head is in electronic communication with the base unit. The therapy head includes a replaceable, sealed transducer cartridge with a coupling fluid therein. A cooling system is provided for cooling the coupling fluid. A plurality of guide indicators are positioned around the therapy head to align with crossed lines on a patient so as to properly align the therapy head prior to use. The therapy head can provide variable treatments to an area while the therapy head is in contact with a patient.

Abstract translation: 医疗超声系统 包括系统电子设备，用户界面和超声波控制电子设备的基本单元。 超声治疗头与基本单元电子通信。 治疗头包括其中具有耦合流体的可更换密封的换能器筒。 提供冷却系统以冷却耦合流体。 多个引导指示器位于治疗头周围以与患者上的交叉线对准，以便在使用之前使治疗头正确对准。 治疗头可以在治疗头与患者接触时向区域提供可变治疗。

公开(公告)号：WO2010102128A1

公开(公告)日：2010-09-10

申请号：PCT/US2010/026240

申请日：2010-03-04

Applicant: MEDICIS TECHNOLOGIES CORPORATION ,  ULRIC, Tanar ,  DESILETS, Charles S. ,  LITTLE, Blake

Inventor： ULRIC, Tanar ,  DESILETS, Charles S. ,  LITTLE, Blake

IPC: A61N7/02

CPC classification number: A61N7/02 ,  A61B34/30 ,  A61N2007/0008 ,  A61N2007/0082 ,  A61N2007/0091 ,  A61N2007/0095

Abstract: Methods and apparatus (100) are described for modifying unwanted tissue for cosmetic reasons. The methods provide a non-invasive manner to perform body contouring by destroying adipose tissue while simultaneously causing collagen contraction in a single procedure. Adipose tissue destroyed during the medical procedure may be removed from a treatment volume during the wound healing process, allowing the treatment volume to gradually shrink (22). The gradual shrinkage may promote better skin tone in the treatment area. The procedure may involve multiple treatments to the same treatment area or location.

Abstract translation: 描述了用于由于化妆品原因修改不想要的组织的方法和装置（100）。 该方法通过破坏脂肪组织同时在单个过程中引起胶原收缩来提供非侵入性的方式来进行身体轮廓。 在伤口愈合过程中，在医疗过程中破坏的脂肪组织可以从治疗体积中移除，使治疗体积逐渐收缩（22）。 逐渐收缩可以促进治疗区域的更好的肤色。 该程序可以涉及对相同治疗区域或位置的多种治疗。

公开(公告)号：WO2010101532A1

公开(公告)日：2010-09-10

申请号：PCT/SI2010000009

申请日：2010-03-02

Applicant: ISKRA MEDICAL D O O ,  JELENC JURE ,  JELENC JOZE

Inventor： JELENC JURE ,  JELENC JOZE

IPC: A61N7/00 ,  A61B18/14 ,  A61H7/00

CPC classification number: A61N7/02 ,  A61B18/14 ,  A61B18/1815 ,  A61B18/20 ,  A61B2017/00106 ,  A61B2017/22008 ,  A61B2018/00005 ,  A61B2018/00452 ,  A61B2018/00994 ,  A61H7/008 ,  A61H23/0245 ,  A61N2007/0008

Abstract: The invention relates to a device for treatment of subcutaneous fat cells, specifically to a device that uses low- and mid-frequency ultrasound waves in combination with radial deep skin therapy. A low- and mid-frequency focused ultrasound device for cavitation in combination with radial deep therapy that comprises a handle (1), a fastening ring (3), a bell-shaped housing (2), an ultrasound source and a vacuum pump, characterized in that low-frequency ultrasound cavitation therapy is performed simultaneously with vacuum therapy with a skin fold, and additionally characterized in that excess gel is removed via a filtration system in the handle.

Abstract translation: 本发明涉及一种用于治疗皮下脂肪细胞的装置，具体涉及一种使用低频和中频超声波以及径向深层皮肤疗法的装置。 本发明涉及一种用于空化的低频和中频聚焦超声装置，其结合包括手柄（1），紧固环（3），钟形壳体（2），超声源和真空泵的径向深度疗法， 其特征在于低频超声空化治疗与利用皮肤皱褶的真空治疗同时进行，并且额外的特征在于通过手柄中的过滤系统去除过量的凝胶。