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1.发明申请
公开(公告)号：WO2023081471A1
公开(公告)日：2023-05-11
申请号：PCT/US2022/049142
申请日：2022-11-07
Applicant: DANA-FARBER CANCER INSTITUTE, INC. , ABVIRO LLC
Inventor： MARASCO, Wayne A. , RAMSTEDT, Hans Urban
Abstract: The present invention provides structural determinants important for binding to the stem domain of the HA protein of influenza virus, and methods of use thereof for production of high affinity neutralizing influenza virus antibodies based upon these determinants. The present invention further provides tools for determining the efficacy of an influenza virus vaccine. The present invention further provides a molecular signature useful for determining the efficacy of an influenza virus vaccine in a subject, or for predicting prior immunologic exposure or antigen responsiveness to vaccine or influenza virus infection.
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