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1.发明申请METHODS FOR DECOUPLING CELL GROWTH FROM PRODUCTION OF BIOCHEMICALS AND RECOMBINANT POLYPEPTIDES 审中-公开从生物化学和重组多肽制备细胞生长的方法
公开(公告)号：WO2018020012A1
公开(公告)日：2018-02-01
申请号：PCT/EP2017/069197
申请日：2017-07-28
发明人： LI, Songyuan , JENDRESEN, Christian Bille , PEDERSEN, Lasse Ebdrup , LANDBERG, Jenny , FALKENBERG, Kristoffer Back , MUNDHADA, Hemanshu , NIELSEN, Alex Toftgaard
摘要： The present invention generally relates to industrial microbiology, and specifically to the production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, and recombinant polypeptides using genetically modified microorganisms. More particularly, the present invention pertains to the decoupling of cell growth from production of biochemical compounds, such as L-serine, L-tyrosine, mevalonate and their derivatives, in a microorganism by down regulating the nucleotide biosynthesis in said microorganism.
摘要翻译： 本发明一般涉及工业微生物学，具体涉及生物化学化合物（例如L-丝氨酸，L-酪氨酸，甲羟戊酸及其衍生物）和使用基因修饰的微生物的重组多肽的生产。 更具体地说，本发明涉及通过下调所述微生物中的核苷酸生物合成，在微生物中使细胞生长与生物化合物（例如L-丝氨酸，L-酪氨酸，甲羟戊酸及其衍生物）的生成脱钩。
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2.发明申请GENETICALLY MODIFIED MICROORGANISMS HAVING IMPROVED TOLERANCE TOWARDS L-SERINE 审中-公开具有改善趋势的L-SERINE的遗传修饰微生物
公开(公告)号：WO2016120345A1
公开(公告)日：2016-08-04
申请号：PCT/EP2016/051728
申请日：2016-01-27
CPC分类号： C12N1/36 , C07K14/245 , C07K14/32 , C12N9/0006 , C12N9/1014 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/1247 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/01 , C12N15/52 , C12P13/001 , C12P13/06 , C12P13/12 , C12P13/22 , C12P17/165 , C12P17/167 , C12Y101/01003 , C12Y101/01095 , C12Y201/02001 , C12Y206/01052 , C12Y207/02003 , C12Y301/03003 , C12Y403/01017
摘要： The present invention generally relates to the microbiological industry, and specifically to the production of L-serine or L-serine derivatives using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
摘要翻译： 本发明一般涉及微生物工业，特别涉及使用转基因细菌生产L-丝氨酸或L-丝氨酸衍生物。 本发明提供了遗传修饰的微生物，例如细菌，其中编码参与L-丝氨酸降解的酶的基因的表达被减弱，例如通过失活，这使得它们特别适用于在较高的L-丝氨酸生产中 产量。 本发明还提供了使微生物，特别是细菌可以制备成更高浓度丝氨酸的耐受性的方法。 本发明还提供使用这种转基因微生物生产L-丝氨酸或L-丝氨酸衍生物的方法。
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3.发明申请METHOD FOR THE PRODUCTION OF L-SERINE USING GENETICALLY ENGINEERED MICROORGANISMS DEFICIENT IN SERINE DEGRADATION PATHWAYS 审中-公开使用遗传工程化微生物生产L-丝氨酸的方法在丝氨酸降解途径中缺乏
公开(公告)号：WO2016120326A1
公开(公告)日：2016-08-04
申请号：PCT/EP2016/051701
申请日：2016-01-27
CPC分类号： C12N1/36 , C07K14/245 , C07K14/32 , C12N9/0006 , C12N9/1014 , C12N9/1096 , C12N9/1205 , C12N9/1217 , C12N9/1247 , C12N9/16 , C12N9/88 , C12N9/90 , C12N9/93 , C12N15/01 , C12N15/52 , C12P13/001 , C12P13/06 , C12P13/12 , C12P13/22 , C12P17/165 , C12P17/167 , C12Y101/01003 , C12Y101/01095 , C12Y201/02001 , C12Y206/01052 , C12Y207/02003 , C12Y301/03003 , C12Y403/01017
摘要： The present invention generally relates to the microbiological industry, and specifically to the production of L-serine using genetically modified bacteria. The present invention provides genetically modified microorganisms, such as bacteria, wherein the expression of genes encoding for enzymes involved in the degradation of L-serine is attenuated, such as by inactivation, which makes them particularly suitable for the production of L-serine at higher yield. The present invention also provides means by which the microorganism, and more particularly a bacterium, can be made tolerant towards higher concentrations of serine. The present invention also provides methods for the production of L-serine or L-serine derivative using such genetically modified microorganisms.
摘要翻译： 本发明一般涉及微生物工业，特别涉及使用转基因细菌生产L-丝氨酸。 本发明提供了遗传修饰的微生物，例如细菌，其中编码参与L-丝氨酸降解的酶的基因的表达被减弱，例如通过失活，这使得它们特别适用于在较高的L-丝氨酸生产中 产量。 本发明还提供了使微生物，特别是细菌可以制备成更高浓度丝氨酸的耐受性的方法。 本发明还提供使用这种转基因微生物生产L-丝氨酸或L-丝氨酸衍生物的方法。
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