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公开(公告)号：WO2019058001A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/076034
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： BALCH, Nathalie , BLOMQUIST, Paul , DOTEN, Reed , HOUSTON, Peter , LAM, Ethan , MCMAHON, Jenna , TRUEHEART, Joshua , VIAROUGE, Celine , DE JONG, René, Marcel
Abstract: The present invention is related to production of retinyl esters, such as in particular retinyl acetate, an important building block for production of vitamin A. The retinyl esters might be generated via enzymatic conversion of retinol which process includes the use of enzymes with acetyl-transferase (ATF) activity, thus acetylating retinol into retinol/retinyl acetate. Said process is particularly useful for biotechnological production of vitamin A.
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公开(公告)号：WO2019058000A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/076033
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： BALCH, Nathalie , BLOMQUIST, Paul , DOTEN, Reed , HOUSTON, Peter , LAM, Ethan , MCMAHON, Jenna , TRUEHEART, Joshua , VIAROUGE, Celine
Abstract: The present invention is related to a novel enzymatic process for production of retinoids via a multi-step process, which process includes the use of heterologous enzymes having activity in a carotene-producing host cell, particularly wherein such process results in high percentage of retinoids, in trans-isoform.
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Patent Agency Ranking
公开(公告)号：WO2019057998A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/076031
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： BALCH, Nathalie , BLOMQUIST, Paul , DOTEN, Reed , HOUSTON, Peter , LAM, Ethan , MCMAHON, Jenna , TRUEHEART, Joshua , VIAROUGE, Celine
Abstract: The present invention is related to a novel enzymatic process for production of vitamin A alcohol (retinol) via conversion of retinal, which process includes the use of heterologous enzymes having activity as retinal reductase, particularly wherein the reaction leads to at least about 90% conversion of retinal into retinol. Said process is particularly useful for biotechnological production of vitamin A.
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公开(公告)号：WO2020141168A1
公开(公告)日：2020-07-09
申请号：PCT/EP2019/087183
申请日：2019-12-30
Applicant: DSM IP ASSETS B.V.
Inventor： HOUSTON, Peter, Louis , DE JONG, René, Marcel , VERWAAL, René , VYAS, Valmik, Kanubhai , MCMAHON, Jenna , SYMBOR-NAGRABSKA, Anna
Abstract: The present invention is related to production of retinyl acetate generated via enzymatic conversion of retinol, said process including the use of modified enzymes with improved activity.
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公开(公告)号：WO2019057996A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/076021
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： BALCH, Nathalie , BLOMQUIST, Paul , DOTEN, Reed , HOUSTON, Peter , LAM, Ethan , MCMAHON, Jenna , TRUEHEART, Joshua , VIAROUGE, Celine
Abstract: The present invention is related to a novel enzymatic process for production of retinyl esters, such as in particular retinyl long chain esters, via conversion of retinol, which process includes the use of enzymes having acyltransferase activity. Said process might be used for biotechnological production of vitamin A.
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公开(公告)号：WO2023067030A1
公开(公告)日：2023-04-27
申请号：PCT/EP2022/079143
申请日：2022-10-19
Applicant: DSM IP ASSETS B.V.
Inventor： VYAS, Valmik Kanubhai , HOUSTON, Peter Louis , MCMAHON, Jenna , DE JONG, René Marcel
Abstract: The present invention is related to bio-production of retinoids with improved purity profile, particularly bio-retinoids with a high percentage of retinyl acetate, wherein the flux towards retinol is increased and wherein the percentage of unwanted by-products such as dihydroretinoids or retinal is minimized to a range of below 10% by expressing retinol dehydrogenase (EC 1.1.1.105, RDH22) derived from Yarrowia lipolytica (Candida lipolytica) or Wickerhamomyces anomalus (Hanensula anomala).
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公开(公告)号：WO2019057999A1
公开(公告)日：2019-03-28
申请号：PCT/EP2018/076032
申请日：2018-09-25
Applicant: DSM IP ASSETS B.V.
Inventor： BALCH, Nathalie , BLOMQUIST, Paul , DOTEN, Reed , HOUSTON, Peter , LAM, Ethan , MCMAHON, Jenna , TRUEHEART, Joshua , VIAROUGE, Celine , DE JONG, René, Marcel
Abstract: The present invention is related to a novel enzymatic process for production of vitamin A aldehyde (retinal) via stereoselective conversion of beta-carotene which process includes the use of trans-selective enzymes having activity as beta-carotene oxidases (BCOs), in particular having preference for trans-retinal. 5 Said process is in particular useful for biotechnological production of vitamin A.
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