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公开(公告)号:WO2014031979A1
公开(公告)日:2014-02-27
申请号:PCT/US2013/056428
申请日:2013-08-23
Applicant: DYER, Cheryl, A. , MAYER, Lorretta, P.
Inventor: MAYER, Lorretta, P.
IPC: A01K67/00 , A61K31/336 , A61K31/665
CPC classification number: A61K31/665 , A01K2207/20 , A61K31/336 , A61K31/343 , A61K31/585 , A61K2300/00
Abstract: Provided are compositions and methods for reducing the reproductive capacity of mammals. The compositions and methods involve the use and administration of (a) a diterpenoid epoxide comprising a triptolide skeleton and which causes ovarian follicle depletion in female mammals and (b) an organic diepoxide which causes ovarian follicle depletion in female mammals.
Abstract translation: 提供了用于降低哺乳动物的繁殖能力的组合物和方法。 组合物和方法涉及(a)包含雷公藤内酯骨架的二萜类环氧化物的使用和给药,其导致雌性哺乳动物的卵泡消耗,和(b)导致雌性哺乳动物卵巢卵泡消耗的有机二环氧化物。