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    METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR NON-INVASIVE DETERMINATION OF BLOOD FLOW DISTRIBUTION USING SPECKLE IMAGING TECHNIQUES AND HEMODYNAMIC MODELING
    1.
    发明申请
    METHODS, SYSTEMS AND COMPUTER PROGRAM PRODUCTS FOR NON-INVASIVE DETERMINATION OF BLOOD FLOW DISTRIBUTION USING SPECKLE IMAGING TECHNIQUES AND HEMODYNAMIC MODELING 审中-公开
    方法，系统和计算机程序产品，用于使用条形图像技术和血液动力学建模对血液流量分布进行非入侵检测

    公开(公告)号：WO2012096878A2

    公开(公告)日：2012-07-19

    申请号：PCT/US2012/020626

    申请日：2012-01-09

    Applicant: EAST CAROLINA UNIVERSITY ,  FERGUSON, Thomas, Bruce, Jr. ,  HU, Xin-Hua ,  CHEN, Cheng

    Inventor： FERGUSON, Thomas, Bruce, Jr. ,  HU, Xin-Hua ,  CHEN, Cheng

    IPC: A61B5/00 ,  A61B5/026 ,  A61B5/02 ,  G02B27/48

    CPC classification number: A61B5/0261 ,  A61B5/0059 ,  A61B5/02007 ,  G02B27/48 ,  G06T7/0012

    Abstract: A non-invasive method for measuring blood flow in principal vessels of a heart of a subject is provided. The method includes illuminating a region of interest in the heart with a coherent light source, wherein the coherent light source has a wavelength of from about 600 nm to about 1100 nm; sequentially acquiring at least two speckle images of the region of interest in the heart during a fixed time period, wherein sequentially acquiring the at least two speckle images comprises acquiring the at least two speckle images in synchronization with motion of the heart of the subject; and electronically processing the at least two acquired speckle images based on the temporal variation of the pixel intensities in the at least two acquired speckle images to generate a laser speckle contrast imaging (LSCI) image and determine spatial distribution of blood flow rate in the principal vessels and quantify perfusion distribution in tissue in the region of interest in the heart from the LSCI image.

    Abstract translation: 提供了一种用于测量受试者心脏主要血管中血流的非侵入性方法。 该方法包括用相干光源照射心脏中的感兴趣区域，其中相干光源具有约600nm至约1100nm的波长; 在固定时间段内依次获取心脏中​​的感兴趣区域的至少两个散斑图像，其中顺序获取所述至少两个斑点图像包括与所述对象的心脏的运动同步地获取所述至少两个斑点图像; 以及基于所述至少两个获取的散斑图像中的像素强度的时间变化来电子处理所述至少两个获取的斑点图像，以产生激光散斑对比成像（LSCI）图像，并且确定主要血管中的血流速率的空间分布 并从LSCI图像中量化心脏中感兴趣区域的组织中的灌注分布。

    METHODS AND SYSTEMS FOR OPTICALLY CHARACTERIZING A TURBID MATERIAL USING A STRUCTURED INCIDENT BEAM
    2.
    发明申请
    METHODS AND SYSTEMS FOR OPTICALLY CHARACTERIZING A TURBID MATERIAL USING A STRUCTURED INCIDENT BEAM 审中-公开
    用结构化偶发光束光学表征涡轮材料的方法和系统

    公开(公告)号：WO2010039921A2

    公开(公告)日：2010-04-08

    申请号：PCT/US2009/059174

    申请日：2009-10-01

    Applicant: EAST CAROLINA UNIVERSITY ,  HU, Xin-Hua ,  CHEN, Cheng

    Inventor： HU, Xin-Hua ,  CHEN, Cheng

    IPC: G01N21/17 ,  G01B11/02 ,  G01N21/41 ,  G01N21/47 ,  G01N33/483

    CPC classification number: G01N21/4738 ,  G01N21/4785 ,  G01N2021/4709 ,  G01N2021/4735 ,  G01N2201/0635

    Abstract: Methods and systems for optically characterizing a turbid sample are provided. A structured light beam is impinged on the sample. The sample includes an embedded region. A reflected light image of the structured light beam is detected from the sample. A measured reflectance image of the structured light beam for the sample is determined based on the reflected light image and a reflectance standard. The following parameters are determined: absorption coefficients ÿa, scattering coefficient ÿs and anisotropy factor g of the sample from the reflectance image. A size parameter of the embedded region is estimated based on the absorption coefficients ÿa, scattering coefficient ÿs and/or anisotropy factor g of the sample from the measured reflectance image.

    Abstract translation: 提供了用于光学表征混浊样品的方法和系统。 结构化光束撞击样品。 样本包括一个嵌入区域。 从样品中检测结构光束的反射光图像。 基于反射光图像和反射率标准确定样品的结构化光束的测量反射率图像。 确定以下参数：来自反射图像的样品的吸收系数ÿa，散射系数ÿs和各向异性因子g。 基于来自测量的反射率图像的样品的吸收系数ÿa，散射系数ÿs和/或各向异性因子g来估计嵌入区域的尺寸参数。

    SYSTEMS FOR DETECTING VASCULAR AND ARTERIAL DISEASE IN ASYMPTOMATIC PATIENTS AND RELATED METHODS
    5.
    发明申请
    SYSTEMS FOR DETECTING VASCULAR AND ARTERIAL DISEASE IN ASYMPTOMATIC PATIENTS AND RELATED METHODS 审中-公开

    公开(公告)号：WO2020081159A2

    公开(公告)日：2020-04-23

    申请号：PCT/US2019/049489

    申请日：2019-09-04

    Applicant: EAST CAROLINA UNIVERSITY

    Inventor： FERGUSON, JR., T. Bruce ,  TUCKER, Bryent ,  KIM, Sunghan ,  CHEN, Cheng ,  HEMPSTEAD, William

    Abstract: Multispectral imaging systems are provided including an illumination control module configured to image a sample and provide an imaging output sequence including images and data; a multi-spectral physiologic visualization (MSPV) module, a peripheral oxygen saturation (SpO 2 ) module and a physiologic status parameters (PSP) module configured to receive the imaging output sequence of the illumination control module simultaneously. The MSPV module is configured to provide real-time blood flow distribution visualization of a field of view (FOV) responsive to the received imaging output sequence. The SpO 2 module is configured to provide real-time SpO 2 information at a tissue surface level for the FOV responsive to the received imaging and output sequence. The PSP module is configured to derive status parameters in real-time from metadata associated with the received imaging and output sequence of the FOV. The system further includes a processing engine configured to integrate and analyze the real-time blood flow distribution visualization, SpO 2 information and derived status parameters.

    MULTI-SPECTRAL PHYSIOLOGIC VISUALIZATION (MSPV) USING LASER IMAGING METHODS AND SYSTEMS FOR BLOOD FLOW AND PERFUSION IMAGING AND QUANTIFICATION IN AN ENDOSCOPIC DESIGN
    6.
    发明申请
    MULTI-SPECTRAL PHYSIOLOGIC VISUALIZATION (MSPV) USING LASER IMAGING METHODS AND SYSTEMS FOR BLOOD FLOW AND PERFUSION IMAGING AND QUANTIFICATION IN AN ENDOSCOPIC DESIGN 审中-公开

    公开(公告)号：WO2019045971A1

    公开(公告)日：2019-03-07

    申请号：PCT/US2018/045715

    申请日：2018-08-08

    Applicant: EAST CAROLINA UNIVERSITY

    Inventor： CHEN, Cheng ,  FERGUSON, JR., T. Bruce ,  JACOBS, Kenneth Michael

    IPC: A61B5/026 ,  A61B1/04 ,  A61B1/06 ,  A61B1/313 ,  A61B1/005 ,  A61B5/00 ,  A61B1/00

    Abstract: Multispectral imaging systems are provided including a first light source having a first wavelength configured to image a sample; a second light source, different from the first light source, having a second wavelength, different from the first wavelength, configured to image the sample; and at least a third light source, different from the first and second light sources, having a third wavelength, different from the first and second wavelengths, configured to image the sample. A camera is configured to receive information related to the first, second and at least third light sources from the sample. A processor is configured to combine the information related to the first, second and at least third light sources provided by the camera to image an anatomical structure of the sample, image physiology of blood flow and perfusion of the sample and/or synthesize the anatomical structure and the physiology of blood flow and perfusion of the sample in terms of a blood flow rate distribution. The imaging system is directed and focused on a field of view (FOV) in a region of interest of the sample using an endoscope.

    MULTI-SPECTRAL LASER IMAGING (MSLI) METHODS AND SYSTEMS FOR BLOOD FLOW AND PERFUSION IMAGING AND QUANTIFICATION
    8.
    发明申请
    MULTI-SPECTRAL LASER IMAGING (MSLI) METHODS AND SYSTEMS FOR BLOOD FLOW AND PERFUSION IMAGING AND QUANTIFICATION 审中-公开
    多光谱成像（MSLI）用于血液流动和灌注成像和量化的方法和系统

    公开(公告)号：WO2016153741A1

    公开(公告)日：2016-09-29

    申请号：PCT/US2016/020201

    申请日：2016-03-01

    Applicant: EAST CAROLINA UNIVERSITY

    Inventor： CHEN, Cheng ,  FERGUSON, T. Bruce, Jr. ,  PENG, Zhiyong ,  JACOBS, Kenneth Michael

    IPC: G01N21/359 ,  G01N33/49

    CPC classification number: A61B5/0261 ,  A61B5/0077 ,  A61B5/7207 ,  A61B5/721 ,  A61B5/7271 ,  A61B2576/00

    Abstract: Some embodiments of the present inventive concept provide a system that uses two wavelengths of differential transmittance through a sample to apply laser speckle or laser Doppler imaging. A first of the two wavelengths is within the visible range that has zero or very shallow penetration. This wavelength captures the anatomical structure of tissue/organ surface and serves as a position marker of the sample but not the subsurface movement of blood flow and perfusion. A second wavelength is in the near Infra-Red (NIR) range, which has much deeper penetration. This wavelength reveals the underlying blood flow physiology and correlates both to the motion of the sample and also the movement of blood flow and perfusion. Thus, true motion of blood flow and perfusion can be derived from the NIR imaging measurement without being affected by the motion artifact of the target.

    Abstract translation: 本发明构思的一些实施例提供一种使用通过样品的两个透射率差的透射率来施加激光斑点或激光多普勒成像的系统。 两个波长中的第一个在可见范围内具有零或非常浅的穿透。 该波长捕获组织/器官表面的解剖结构，并且用作样品的位置标记，而不是血流和灌注的地下运动。 第二波长处于近红外（NIR）范围，穿透深度更深。 这种波长显示出潜在的血流生理学，并且与样本的运动以及血流和灌注的运动相关。 因此，可以从NIR成像测量中导出血流和灌注的真实运动，而不受目标运动伪影的影响。

    SYSTEMS FOR DETECTING VASCULAR AND ARTERIAL DISEASE IN ASYMPTOMATIC PATIENTS AND RELATED METHODS
    9.
    发明申请
    SYSTEMS FOR DETECTING VASCULAR AND ARTERIAL DISEASE IN ASYMPTOMATIC PATIENTS AND RELATED METHODS 审中-公开

    公开(公告)号：WO2020081159A3

    公开(公告)日：2020-04-23

    申请号：PCT/US2019/049489

    申请日：2019-09-04

    Applicant: EAST CAROLINA UNIVERSITY

    Inventor： FERGUSON, JR., T. Bruce ,  TUCKER, Bryent ,  KIM, Sunghan ,  CHEN, Cheng ,  HEMPSTEAD, William

    IPC: G16H30/40 ,  G16H50/70 ,  A61B5/026 ,  A61B5/1455

    Abstract: Multispectral imaging systems are provided including an illumination control module configured to image a sample and provide an imaging output sequence including images and data; a multi-spectral physiologic visualization (MSPV) module, a peripheral oxygen saturation (SpO 2 ) module and a physiologic status parameters (PSP) module configured to receive the imaging output sequence of the illumination control module simultaneously. The MSPV module is configured to provide real-time blood flow distribution visualization of a field of view (FOV) responsive to the received imaging output sequence. The SpO 2 module is configured to provide real-time SpO 2 information at a tissue surface level for the FOV responsive to the received imaging and output sequence. The PSP module is configured to derive status parameters in real-time from metadata associated with the received imaging and output sequence of the FOV. The system further includes a processing engine configured to integrate and analyze the real-time blood flow distribution visualization, SpO 2 information and derived status parameters.

    DETERMINING PERIPHERAL OXYGEN SATURATION (SPO2) AND HEMOGLOBIN CONCENTRATION USING MULTI-SPECTRAL LASER IMAGING (MSLI) METHODS AND SYSTEMS
    10.
    发明申请
    DETERMINING PERIPHERAL OXYGEN SATURATION (SPO2) AND HEMOGLOBIN CONCENTRATION USING MULTI-SPECTRAL LASER IMAGING (MSLI) METHODS AND SYSTEMS 审中-公开

    公开(公告)号：WO2019236847A1

    公开(公告)日：2019-12-12

    申请号：PCT/US2019/035792

    申请日：2019-06-06

    Applicant: EAST CAROLINA UNIVERSITY

    Inventor： TUCKER, Bryent ,  FERGUSON, JR., T. Bruce ,  CHEN, Cheng

    IPC: A61B5/00 ,  A61B5/1455

    Abstract: Some embodiments of the present inventive concept provide a multispectral imaging system including a first light source, the first light source having a first wavelength configured to produce a non-coherent illumination to image a sample; a second coherent light source, different from the first light source, having a second wavelength, different from the first wavelength, configured to image the sample simultaneously with the first light source; a camera configured to simultaneously receive information related to the first and second light sources from the sample, wherein light at the first wavelength is configured to image a surface of the sample into the camera and light at the second wavelength is configured to penetrate the sample and provide information related to the penetrated sample to the camera; and a processor configured to combine the received information related to the first and second light sources and generate a synthesized image of the anatomical structure and the physiology of blood flow and perfusion of the sample in terms of blood flow rate distribution.

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