公开(公告)号：WO2019217387A1

公开(公告)日：2019-11-14

申请号：PCT/US2019/031072

申请日：2019-05-07

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia- derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

公开(公告)号：WO2020076857A1

公开(公告)日：2020-04-16

申请号：PCT/US2019/055239

申请日：2019-10-08

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： Compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. Malassezia -derived compounds and/or chemical analogs thereof, compositions that comprise such compounds, and methods of treating by administering the compounds and compositions, including methods of inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, and melanin concentration.

公开(公告)号：WO2019241706A1

公开(公告)日：2019-12-19

申请号：PCT/US2019/037311

申请日：2019-06-14

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia - derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.

公开(公告)号：WO2019200232A1

公开(公告)日：2019-10-17

申请号：PCT/US2019/027181

申请日：2019-04-12

申请人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

发明人： EINZIGER, Michael ,  SIMPSON, Ann, Marie

IPC分类号： C07D487/04 ,  A61K8/49 ,  A61Q19/02 ,  C07D209/12 ,  A61P17/00 ,  A61K31/404

摘要： The present invention relates to compounds, compositions, and methods for modulating skin pigmentation and treating or preventing UV-induced skin damage, erythema, aging of the skin, sunburn, and hyperpigmentation in a subject. The compounds, compositions, and methods of the present invention generally involve Malassezia -derived compounds, including malassezin and indirubin, and/or chemical analogs thereof. Other applications of the compounds and compositions disclosed herein include, but are not limited to, improving hyperpigmentation caused by a hyperpigmentation disorder, inducing melanocyte apoptosis, and modulating arylhydrocarbon receptor (AhR) activity, melanogenesis, melanin production, melanosome biogenesis, melanosome transfer, melanocyte activity, and melanin concentration.