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公开(公告)号：WO2017087667A9
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice Sun , CHAN, Betty , SMITH, Peter G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian Huat
IPC分类号： C07D405/06 , A61K31/4427 , A61P35/00
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号：WO2017087667A8
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice Sun , CHAN, Betty , SMITH, Peter G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian Huat
IPC分类号： C07D405/06 , A61K31/4427 , A61P35/00
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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