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公开(公告)号：WO2019232449A1
公开(公告)日：2019-12-05
申请号：PCT/US2019/035015
申请日：2019-05-31
发明人： PAZOLLI, Ermira , BUONAMICI, Silvia , SAMARAKOON, Thiwanka , PRAJAPATI, Sudeep , FISHKIN, Nathan , PALACINO, James , SEILER, Michael , ZHU, Ping , COOK, Andrew , SMITH, Peter , LIU, Xiang , ELLERY, Shelby , REYNOLDS, Dominic , YU, Lihua , WU, Zhenhua , PENG, Shouyong , CALANDRA, Nicholas , SHEEHAN, Megan , XIAO, Yonghong
摘要： Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
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公开(公告)号：WO2019232449A9
公开(公告)日：2019-12-05
申请号：PCT/US2019/035015
申请日：2019-05-31
发明人： PAZOLLI, Ermira , BUONAMICI, Silvia , SAMARAKOON, Thiwanka , PRAJAPATI, Sudeep , FISHKIN, Nathan , PALACINO, James , SEILER, Michael , ZHU, Ping , COOK, Andrew , SMITH, Peter , LIU, Xiang , ELLERY, Shelby , REYNOLDS, Dominic , YU, Lihua , WU, Zhenhua , PENG, Shouyong , CALANDRA, Nicholas , SHEEHAN, Megan , XIAO, Yonghong
摘要： Linker-drug compounds and antibody-drug conjugates that bind to human oncology targets are disclosed. The linker-drug compounds and antibody-drug conjugates comprise a splicing modulator drug moiety. The disclosure further relates to methods and compositions for use in the treatment of neoplastic disorders by administering the antibody-drug conjugates provided herein. In an embodiment, the splicing modulator comprises a pladienolide or a pladienolide derivative.
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公开(公告)号：WO2019232433A3
公开(公告)日：2019-12-05
申请号：PCT/US2019/034992
申请日：2019-05-31
发明人： PAZOLLI, Ermira , BUONAMICI, Silvia , PALACINO, James , SEILER, Michael , ZHU, Ping , BARRY, Evan , YU, Lihua
摘要： This disclosure relates to methods for the treatment of neoplastic disorders by administering Compound 1, or a pharmaceutically acceptably salt thereof, on its own and/or as part of a conjugate or composition, and inducing production of at least one neoantigen.
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公开(公告)号：WO2021248005A1
公开(公告)日：2021-12-09
申请号：PCT/US2021/035913
申请日：2021-06-04
发明人： HENRY, Ryan , SAMARAKOON, Thiwanka , FISHKIN, Nathan , ZHU, Ping , PAZOLLI, Ermira , PALACINO, James , ALMAGRO, Juan
IPC分类号： C07K16/28 , A61K47/68 , A61P35/02 , C07D405/06 , C07D405/14 , C07D407/06 , A61K39/00 , A61K2039/505 , A61K47/6803 , A61K47/6849 , A61K47/6867 , A61K47/6889 , C07K16/2878 , C07K2317/565
摘要： Antibodies, antigen-binding fragments, and conjugates (e.g., antibody-drug conjugates (ADCs) such as those comprising a splicing modulator) that bind to BCMA are disclosed. The disclosure further relates to methods and compositions for use in the treatment of cancer by administering a composition provided herein.
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公开(公告)号：WO2017087667A9
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice Sun , CHAN, Betty , SMITH, Peter G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian Huat
IPC分类号： C07D405/06 , A61K31/4427 , A61P35/00
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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公开(公告)号：WO2019232433A2
公开(公告)日：2019-12-05
申请号：PCT/US2019/034992
申请日：2019-05-31
发明人： PAZOLLI, Ermira , BUONAMICI, Silvia , PALACINO, James , SEILER, Michael , ZHU, Ping , BARRY, Evan , YU, Lihua
IPC分类号： A61K31/496 , A61P35/00 , A61P35/02 , A61P43/00
摘要： This disclosure relates to methods for the treatment of neoplastic disorders by administering Compound 1, or a pharmaceutically acceptably salt thereof, on its own and/or as part of a conjugate or composition, and inducing production of at least one neoantigen.
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公开(公告)号：WO2017087667A8
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice Sun , CHAN, Betty , SMITH, Peter G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian Huat
IPC分类号： C07D405/06 , A61K31/4427 , A61P35/00
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
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8.发明申请A SOLID STATE FORM OF PLADIENOLIDE PYRIDINE COMPOUNDS AND METHODS OF USE 审中-公开普拉地尼德吡啶类化合物的固态形式及使用方法
公开(公告)号：WO2017087667A1
公开(公告)日：2017-05-26
申请号：PCT/US2016/062525
申请日：2016-11-17
申请人： EISAI R&D MANAGEMENT CO., LTD. , KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo, Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , GEARHART, Nicholas C. , KOTAKE, Yoshihiko , NAGAO, Satoshi , KANADA SONABE, Regina, Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice, Sun , CHAN, Betty , SMITH, Peter, G. , THOMAS, Michael P. , PAZOLLI, Ermira , LIM, Kian, Huat
发明人： KEANEY, Gregg F. , WANG, John , GERARD, Baudouin , ARAI, Kenzo , LIU, Xiang , ZHENG, Guo, Zhu , KIRA, Kazunobu , TIVITMAHAISOON, Parcharee , PRAJAPATI, Sudeep , KOTAKE, Yoshihiko , KANADA SONABE, Regina, Mikie , MIYANO, Masayuki , MURAI, Norio , BUONAMICI, Silvia , YU, Lihua , PARK, Eunice, Sun , SMITH, Peter, G. , PAZOLLI, Ermira , LIM, Kian, Huat
IPC分类号： C07D405/06 , A61K31/4427 , A61P35/00
CPC分类号： C07D405/06
摘要： The present disclosure provides a novel solid state form of pladienolide pyridine compounds, compositions comprising at least one such solid state form, and methods of preparation and use and the same. The novel solid state form of pladienolide pyridine compounds may be useful in the treatment of cancer, such as, for example, cancers in which agents that target the spliceosome and mutations therein are known to be useful.
摘要翻译： 本公开提供了一种新型固体形式的普拉二烯内酯吡啶化合物，包含至少一种此类固体形式的组合物，以及制备和使用方法及其相关方法。 该新型固体形式的普拉二烯内酯吡啶化合物可用于治疗癌症，例如癌症，其中靶向剪接体的试剂及其突变已知是有用的。
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