专利检索 ap:("ELI LILLY AND COMPANY") AND inv:"CAO, Yizheng" 第 1 页

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发明申请
SOLID FORMS OF 7-[[(1S)-1-[4-[(1S)-2-CYCLOPROPYL-1-(4-PROP-2- ENOYLPIPERAZIN-1-YL)ETHYL]PHENYL]ETHYL]AMINO]-1-ETHYL-4H- PYRIMIDO[4,5-D] [1,3]OXAZIN-2-ONE 审中-公开

公开(公告)号：WO2023018955A1

公开(公告)日：2023-02-16

申请号：PCT/US2022/040191

申请日：2022-08-12

申请人： ELI LILLY AND COMPANY

发明人： COATES, David Andrew , CAO, Yizheng

IPC分类号： A61P35/00 , C07D498/04 , A61K31/5365 , C07C65/05

摘要： Solid forms including 7-[[(1S)-1-[4-[(1S)-2-cyclopropyl-1-(4-prop-2-enoylpiperazin-1-yl)ethyl]phenyl]ethyl]amino]-1-ethyl-4H-pyrimido[4,5-d][1,3]oxazin-2-one and a dihydroxybenzoic acid selected from 2,5-dihydroxybenzoic acid, 2,4-dihydroxybenzoic acid, and 2,3-dihydroxybenzoic acid are provided, as well as pharmaceutical compositions including the solid forms, methods for using the solid forms in treating cancer patients, and methods of making the solid forms.