公开(公告)号：WO2022093793A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056610

申请日：2021-10-26

Applicant: ELUCIDA ONCOLOGY, INC.

Inventor： MA, Kai ,  VENKATESAN, Aranapakam, M. ,  CHEN, Feng ,  WU, Fei ,  TÜRKER, Melik, Ziya ,  GARDINIER, Thomas, Courtney, II ,  GERMANO, Geno, J., Jr. ,  ADAMS, Gregory, Paul ,  LEE, Francis, Y., F.

IPC: A61K47/55 ,  A61K47/69 ,  A61K51/12 ,  A61P35/00 ,  A61K103/00

Abstract: The disclosure relates to nanoparticle drug conjugates (NDC) that comprise ultrasmall nanoparticles, folate receptor (FR) targeting ligands, and linker-drug conjugates, and methods of making and using them to treat cancer.

公开(公告)号：WO2022093794A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056611

申请日：2021-10-26

Applicant: ELUCIDA ONCOLOGY, INC.

Inventor： MA, Kai ,  TÜRKER, Melik, Ziya ,  WU, Fei ,  CHEN, Feng ,  GARDINIER, Thomas, Courtney, II ,  VENKATESAN, Aranapakam M. ,  GERMANO, Geno J., Jr.

IPC: A61K47/69 ,  A61K49/00 ,  A61K47/551 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0032 ,  A61K49/0093 ,  A61K51/1244 ,  A61P35/00

Abstract: This disclosure relates to methods of functionalizing a nanoparticle, e.g., for conjugation to a targeting ligand and/or payload moiety, such as for the production of a nanoparticle drug conjugate (NDC).