公开(公告)号：WO2021054927A2

公开(公告)日：2021-03-25

申请号：PCT/US2019/000039

申请日：2019-08-12

Applicant: SOUTH DAKOTA BOARD OF REGENTS

Inventor： GUAN, Xiangming ,  NAJMI, Asidim ,  WANG, Shenggang ,  HUANG, Yue ,  SEEFELDT, Teresa ,  ALQAHTANI, Yahya

IPC: A61K9/127 ,  A61K9/14 ,  A61K9/51 ,  A61K47/28 ,  A61K38/00 ,  A61K47/20 ,  A61K47/6907 ,  A61K47/6911 ,  A61K49/0032 ,  A61K49/0082 ,  A61K49/0084 ,  A61K9/0019 ,  A61K9/1075 ,  C07K5/0215

Abstract: The present invention describes compositions containing cholesterol-linker-glutathione conjugates for targeting the brain by overcoming barrier entry to the CNS through the blood brain barrier (BBB), including micelle and liposome forms of such compositions. In addition, methods for treating subjects by administering such compositions are also disclosed.

公开(公告)号：WO2022207705A1

公开(公告)日：2022-10-06

申请号：PCT/EP2022/058411

申请日：2022-03-30

Applicant: AGFA-GEVAERT NV

Inventor： LOCCUFIER, Johan ,  LOUWET, Jos

IPC: A61K9/10 ,  A61K9/16 ,  A61K9/51 ,  C08K5/3462 ,  A61K41/00 ,  A61K49/00 ,  A61K41/0057 ,  A61K49/0032 ,  A61K49/0091 ,  A61K9/5153

Abstract: A composite resin particle comprising a near infrared absorber according to general formula I and a resin selected from the group consisting of (poly(amino acids), polyphosphazenes, polysaccahride derivatives, poly(esters), poly(ortho esters), poly(cyano-acrylates) and copolymers thereof (General formula (I)). The composite resin particles are suitable for opto-medical applications such as phototherapies including photothermal therapy (PTT), photodynamic therapy (PDT), chemo-photodynamic nanotherapeutics and fluorescence medical imaging.

公开(公告)号：WO2023275537A1

公开(公告)日：2023-01-05

申请号：PCT/GB2022/051662

申请日：2022-06-28

Applicant: THE UNIVERSITY OF MANCHESTER

Inventor： ZHAO, Can ,  BROMLEY, Mike ,  VENDRELL ESCOBAR, Marc

IPC: A61K49/00 ,  C07K7/06 ,  A61P31/04 ,  A61P31/10 ,  A61P33/04 ,  A61K49/0032 ,  A61K49/0043 ,  A61K49/0056 ,  C07K7/52

Abstract: The present invention relates to compounds of formula (I) and formula (II). The compounds of the invention may be used in a method of treatment of a fungal infection, a bacterial infection, or an ameobic infection.

公开(公告)号：WO2022120206A2

公开(公告)日：2022-06-09

申请号：PCT/US2021/061862

申请日：2021-12-03

Applicant: THE REGENTS OF THE UNIVERSITY OF MICHIGAN

Inventor： KIM, Jinsang ,  ZENG, Yingying ,  KANG, Do, Hyun ,  PAULUS, Yannis ,  NGUYEN, Van, Phuc

IPC: G01N21/64 ,  G01N33/543 ,  G01N33/569 ,  A61K49/0015 ,  A61K49/0032 ,  A61K49/0093

Abstract: Provided herein are room-temperature phosphorescence nanoparticles, methods of preparing the same, and uses of the same.

公开(公告)号：WO2022072949A2

公开(公告)日：2022-04-07

申请号：PCT/US2021/053439

申请日：2021-10-04

Applicant: THE GENERAL HOSPITAL CORPORATION

Inventor： CARLSON, Jonathan ,  MIKULA, Hannes ,  WEISSLEDER, Ralph

IPC: C07D257/08 ,  C07D401/04 ,  C07D403/12 ,  A61K47/55 ,  A61K47/64 ,  A61K49/0023 ,  A61K49/0032 ,  A61K49/0041 ,  A61K49/0058 ,  C07C13/00 ,  C07D233/60 ,  C07D263/52 ,  C07D305/14 ,  C07D309/34 ,  C07D313/04 ,  C07D317/44 ,  C07D471/04 ,  C07D471/14 ,  C07D487/04 ,  C07D487/06 ,  C07D487/12 ,  C07D487/14 ,  C07D491/147 ,  C07D493/14 ,  C07F7/0816 ,  C07K7/00

Abstract: The present disclosure provides bioorthogonal linkers and reagents, including trans-cyclooctene ("TCO")- and tetrazine ("Tz")- containing compounds. In a general aspect, the present disclosure provides reagents, conjugates, and bioactive molecules containing a trans-cyclooctene ("TCO") fragment. Examples of TCO fragments include: Formulae (I) and (II).

公开(公告)号：WO2023057508A1

公开(公告)日：2023-04-13

申请号：PCT/EP2022/077690

申请日：2022-10-05

Applicant: VRIJE UNIVERSITEIT BRUSSEL

Inventor： HERNOT, Sophie ,  DEBIE, Pieterjan

IPC: A61K49/00 ,  A61K49/0032 ,  A61K49/0058

Abstract: The current invention relates to a conjugate comprising an immunoglobulin single variable domain conjugated to one or more detectable labels, wherein at least one of said labels comprises a fluorescent moiety, said fluorescent moiety having a structure chosen from formula (I) or formula (II). The current invention also relates to a conjugate comprising an immunoglobulin single variable domain conjugated to one or more detectable labels, wherein said conjugate exhibits less than 10 percent serum protein binding as measured by HPLC. The invention further relates to a pharmaceutical composition comprising aforementioned conjugate and the use of aforementioned conjugate or composition.

公开(公告)号：WO2022093800A2

公开(公告)日：2022-05-05

申请号：PCT/US2021/056621

申请日：2021-10-26

Applicant: ELUCIDA ONCOLOGY, INC.

Inventor： VENKATESAN, Aranapakam, M. ,  MA, Kai ,  CHEN, Feng ,  WU, Fei ,  TURKER, Melik, Ziya ,  GARDINIER, Thomas, Courtney ,  GERMANO, Geno, J. ,  ADAMS, Gregory, Paul ,  LEE, Francis, Y.F.

IPC: A61K47/55 ,  A61K47/69 ,  A61K51/12 ,  A61P35/00 ,  A61K103/00 ,  A61K49/00 ,  A61K47/551 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0032 ,  A61K49/0093 ,  A61K51/1244

Abstract: The disclosure relates to carrier particle-drug conjugates, including nanoparticle drug conjugates (NDC), that can be used in the delivery of a drug to a biological target (e.g., for targeted delivery of a cytotoxic drug to a cancer cell or tumor). Also disclosed are self- immolative linkers and linker-payload conjugates suitable for use in a carrier particle drug conjugate, and methods of making the same, and methods for treating cancer.

公开(公告)号：WO2021259899A1

公开(公告)日：2021-12-30

申请号：PCT/EP2021/066920

申请日：2021-06-22

Applicant: BRACCO IMAGING SPA

Inventor： BLASI, Francesco ,  BUONSANTI, Federica ,  CRIVELLIN, Federico ,  FERRARIS, Andrea ,  ORIO, Laura ,  PIZZUTO, Lorena ,  NAPOLITANO, Roberta ,  VALBUSA, Giovanni

IPC: C09B23/01 ,  A61K49/00 ,  G01N33/533 ,  G01N33/58 ,  A61K49/0032 ,  A61K49/0052 ,  A61K49/0056 ,  C09B23/0066 ,  G01N33/582

Abstract: The present invention relates to the field of optical imaging. More particularly, it relates to compounds of the cyanine family with near- infrared emission characterized by improved physico-chemical and biological properties and to conjugates with biological ligands thereof. The invention also relates to the use of these compounds as optical diagnostic agents in imaging or therapy of solid tumors, to the methods for their preparation and to the compositions comprising them. The compounds have formula (I), formula (I), wherein X is direct bond or -O-; Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups; R1 and R2 are each independently a linear or branched C1-C6 alkyl substituted by a group selected from -SO3H, -COOH, -CONH2 and - COO-C1-C6 alkyl; and R3 is hydrogen, -SO3H or a linear or branched C1-C6 alkyl substituted by -COOH or -CONH-Y, wherein Y is a group selected from linear or branched C1-C6 alkyl, C3-C7 cycloalkyl and heterocyclyl, substituted by at least two hydroxyl groups.

公开(公告)号：WO2022093794A1

公开(公告)日：2022-05-05

申请号：PCT/US2021/056611

申请日：2021-10-26

Applicant: ELUCIDA ONCOLOGY, INC.

Inventor： MA, Kai ,  TÜRKER, Melik, Ziya ,  WU, Fei ,  CHEN, Feng ,  GARDINIER, Thomas, Courtney, II ,  VENKATESAN, Aranapakam M. ,  GERMANO, Geno J., Jr.

IPC: A61K47/69 ,  A61K49/00 ,  A61K47/551 ,  A61K47/6923 ,  A61K47/6929 ,  A61K49/0032 ,  A61K49/0093 ,  A61K51/1244 ,  A61P35/00

Abstract: This disclosure relates to methods of functionalizing a nanoparticle, e.g., for conjugation to a targeting ligand and/or payload moiety, such as for the production of a nanoparticle drug conjugate (NDC).

公开(公告)号：WO2022093374A8

公开(公告)日：2022-05-05

申请号：PCT/US2021/047827

申请日：2021-08-26

Applicant: PURDUE RESEARCH FOUNDATION

Inventor： LOW, Philip, S. ,  LOW, Stewart ,  NIELSEN, Jeffery

IPC: A61K38/29 ,  A61K9/00 ,  A61P19/08 ,  A61K47/64 ,  A61K49/0032 ,  A61K49/0056 ,  A61K9/0019

Abstract: Osteotropic ligand-bone anabolic agent compounds and related compositions and methods of use to treat spinal fusion.