公开(公告)号：WO2016205389A1

公开(公告)日：2016-12-22

申请号：PCT/US2016/037658

申请日：2016-06-15

Applicant: EMORY UNIVERSITY ,  CHILDREN'S HEALTHCARE OF ATLANTA, INC.

Inventor： MOORE, Martin L. ,  LEE, Sujin ,  NGUYEN, Minh Trang

IPC: A61K39/12 ,  A61K39/13 ,  A61K39/145

CPC classification number: A61K39/125 ,  A61K39/12 ,  A61K2039/5252 ,  A61K2039/545 ,  A61K2039/55505 ,  A61K2039/70 ,  A61P31/16 ,  C12N2770/32334

Abstract: This disclosure relates to multivalent enterovirus vaccine compositions and uses related thereto. In certain embodiments, the disclosure relates to vaccine compositions comprising multivalent, mixtures of enterovirus (for example HRV) serotypes or recombinantly produced variants or recombinantly produced viral capsid proteins. In certain embodiments, the disclosure relates to methods of immunization comprising administering an effective amount of compositions disclosed herein to a subject diagnosed with, exhibiting symptoms of, or at risk of an enterovirus infection.

Abstract translation: 本公开涉及多价肠病毒疫苗组合物及其相关用途。 在某些实施方案中，本公开涉及包含多价，肠道病毒（例如HRV）血清型或重组产生的变体或重组产生的病毒衣壳蛋白的混合物的疫苗组合物。 在某些实施方案中，本公开涉及免疫方法，其包括将有效量的本文公开的组合物施用于被诊断患有肠道病毒感染的症状或具有肠病毒感染风险的受试者。