公开(公告)号：WO2022216750A1

公开(公告)日：2022-10-13

申请号：PCT/US2022/023546

申请日：2022-04-05

Applicant: EPIODYNE, INC.

Inventor： MEDINA, Julio Cesar ,  NERURKAR, Alok ,  SADLOWSKI, Corinne ,  SEIDL, Frederick ,  CHENG, Heng ,  DUQUETTE, Jason ,  LEE, John ,  HOLAN, Martin ,  DING, Pingyu ,  WANG, Xiaodong ,  WIDJAJA, Tien ,  NGUYEN, Thomas ,  BHATT, Ulhas ,  LI, Yihong ,  WEI, Zhi-liang

IPC: C07D277/22 ,  C07D239/26 ,  C07D213/24 ,  C07D307/38 ,  C07D333/06 ,  C07C237/30 ,  C07C237/20 ,  A61P25/00

Abstract: Provided herein are opioid receptor modulators and pharmaceutical compositions comprising said compounds.

公开(公告)号：WO2019195634A1

公开(公告)日：2019-10-10

申请号：PCT/US2019/025910

申请日：2019-04-04

Applicant: EPIODYNE, INC.

Inventor： MEDINA, Julio Cesar ,  MCGEE, Larry ,  WEI, Zhi-Liang ,  SADLOWSKI, Corinne ,  SEIDL, Frederick ,  BHATT, Ulhas ,  WANG, Xiaodong ,  NGUYEN, Thomas ,  SPERANDIO, David ,  DING, Pingyu ,  NERURKAR, Alok ,  LI, Yihong ,  DUQUETTE, Jason

IPC: C07C233/62 ,  C07D213/80 ,  C07C233/65 ,  C07C271/20 ,  C07C271/52 ,  C07C275/24 ,  C07C275/28 ,  C07D213/42 ,  C07D213/56 ,  C07D213/58 ,  C07D217/00 ,  C07D217/14 ,  C07D217/26 ,  C07D241/28 ,  C07D471/04 ,  A61K31/17 ,  A61K31/4402 ,  A61K31/416 ,  A61P25/00

Abstract: Compounds are provided having the structure of Formula (I): or a pharmaceutically acceptable isomer, racemate, hydrate, solvate, isotope, or salt thereof, wherein A, B, L, R 3 , R 4 , R 5 , R 6 , R 8 , m and n are as defined herein. Such compounds modulate the opioid receptor, particulare the mu-opioid receptor (MOR) and/or the kappa-opioid receptor (KOR), and/or the delta-opioid receptor (DOR). Products containing such compounds, as well as methods for their use and preparation, are also provided.