公开(公告)号：WO2009006483A1

公开(公告)日：2009-01-08

申请号：PCT/US2008/068936

申请日：2008-07-01

Applicant: ESSENTIALIS, INC. ,  COWEN, Neil, M. ,  DUKES, Lain

Inventor： COWEN, Neil, M. ,  DUKES, Lain

IPC: A61K31/54

CPC classification number: A61K31/54

Abstract: Provided are immediate or prolonged administration of certain salts of KATP channel openers such as diazoxide to a subject to achieve novel pharmacodynamic, pharmacokinetic, therapeutic, physiological, metabolic and compositional outcomes in the treatment of diseases or conditions involving KATP channels. Also provided are pharmaceutical formulations, methods of administration and dosing of the salts that achieve these outcomes and reduce the incidence of adverse effects in treated individuals. Further provided are method of co-administering the salts with other drugs to treat diseases of humans and animals.

Abstract translation: 提供对受试者立即或长期给予KATP通道开放剂如二氮嗪的某些盐，以在治疗涉及KATP通道的疾病或病症中获得新颖的药效学，药代动力学，治疗学，生理学，代谢和组合结果。 还提供了实现这些结果的药物制剂，施用方法和给药盐，并减少治疗个体的不良反应的发生率。 进一步提供了与其它药物共同施用盐以治疗人和动物疾病的方法。